antimicrobial therapy

Antimicrobials for the treatment of uncomplicated urinary tract infections (UTI) include different drug classes: fluoroquinolones, cephalosporins, beta-lactam/betalactamase inhibitor combinations, aminoglycosides, carbapenems, nitrofurans, …

Currently, treatment of intra-abdominal infections is significantly complicated by increased antimicrobial resistance. Inappropriate antimicrobial therapy is one of the reasons for spread of extended spectrum beta-lactamases (ESBL) both in hospital …

Analysis of antibiotic usage in children living in orphanages was performed during two time-periods: 2003–2004 and 2009–2010 with the aim to reveal key problems of antibiotic usage in this population, and to develop measures for improvement. It was …

Over the last years, short treatment courses for different infections, including respiratory tract infections, are increasingly more discussed. This therapeutic approach has some clear benefits: improved compliance, less frequent adverse drug …

Acute bacterial rhinosinusitis (ABRS) is a common disease in pediatric practice, which takes a fifth place among the causes of antimicrobials administration to children. This paper presents a review of current clinical guidelines on the management of …

This paper presents the results of the study to evaluate knowledge level of ophthalmologists on risk factors, etiology, diagnosis, and treatment of keratitis. A total of 65 ophthalmologists in 3 regions (Smolensk, Kaluga, and Orel) completed …

Successful outcome of complicated intra-abdominal infections (peritonitis) is determined by two key factors – surgical control of infection site and appropriate and timely antimicrobial therapy. Over the years choice of high antimicrobials for the …

Objective. Objectives. To determine the diagnostic and treatment patterns for acute male urethritis (AMU) in Russia. Materials and Methods. Retrospective cross-sectional study was conducted during 2009 in 4 cities of Russia: Kaluga, Pskov, Smolensk and Tula. Data on diagnostic and treatment approaches for AMU subjects ≥16 years old were collected and analyzed using specially designed case report forms. Results. 556 cases of AMU were analyzed during study period. The average age of patients was 29 years (16–68 years).

The emergence and spread of resistance to multiple classes of antimicrobials is a growing threat, especially in microorganisms causing severe nosocomial infections in hospital settings. Tigecycline, the first in a new class of antimicrobials …

Objective. To study prospectively clinical course of hospital-acquired pneumonia (HAP), mortality, and risk factors for poor outcome as well as etiology and antibiotic resistance of HAP in trauma patients; to assess antimicrobial therapy in patients with head trauma and orthopedic trauma in Smolensk Clinical Hospital of Emergency Medical Care. Materials and Methods. A prospective observational study in 96 patients with head trauma or orthopedic trauma and concurrent HAP, confirmed by clinical examination, chest X-ray, and Clinical Pulmonary Infection Scale (CPIS) score of ≥5.