Clinical Microbiology and Antimicrobial Chemotherapy. 2013; 15(4):301-308
Currently, treatment of intra-abdominal infections is significantly complicated by increased antimicrobial resistance. Inappropriate antimicrobial therapy is one of the reasons for spread of extended spectrum beta-lactamases (ESBL) both in hospital and outpatient settings. It was associated with significant decrease in efficacy of cephalosporins in the treatment of intra-abdominal infections. There is also a trend to increase resistance of pathogens to fluoroquinolones. In order to keep antimicrobials with activity against non-fermenting Gramnegative bacteria effective, stratification of patients with intra-abdominal infections by the risk of multidrug resistant pathogens should be performed when administering empiric antibacterial therapy.