intra-abdominal infections

Ceftolozane/tazobactam – the «new player» in a battle against multiresistant pathogens

Ceftolozane/tazobactam is a new combined antibacterial agent for the treatment of infections caused by gram-negative microorganisms, P. aeruginosa in particular, including strains resistant to other clinically available antimicrobials. In this paper …

Antimicrobial Resistance of Gram-negative Microorganisms Causing Complicated Intra-abdominal Infections in Russia

Objective. To assess antimicrobial resistance of gram-negative microorganisms causing complicated intra-abdominal infections (IAI) in Russia. Materials and Methods. This was a multicenter (a total of 21 cities), prospective, microbiological study to collect Gram-negative pathogens from patients with complicated IAI. Identification was performed using MALDITOF mass spectrometry. Minimal inhibitory concentrations (MICs) of antibiotics were determined by dilution method according to the current CLSI and EUCAST guidelines. Results. A total of 1908 isolates of gram-negative pathogens was obtained (357 isolates in community-acquired IAI, and 1551 isolates in nosocomial IAI).

Current View on Antimicrobial Therapy of Intra-Abdominal Infections

Currently, treatment of intra-abdominal infections is significantly complicated by increased antimicrobial resistance. Inappropriate antimicrobial therapy is one of the reasons for spread of extended spectrum beta-lactamases (ESBL) both in hospital …

«Respiratory» Fluoroquinolones – the Neoclassics of Antimicrobial Chemotherapy

«Respiratory» fluoroquinolones, unlike previous generations, have higher activity against Gram-positive pathogens causing important infections in humans. Broad antimicrobial spectrum, ability to overwhelm some bacterial resistance mechanisms, absence …

Antimicrobial Therapy of Intra-Abdominal Infections (According to the guidelines of Surgical Infection Society)

Treatment of intra-abdominal infections (IAI) is а significant problem in surgery. Taking into consideration the clinical practice in Russia, this paper presents an analysis of guidelines on antimicrobial therapy for IAI, developed by Surgical …