Ceftolozane/tazobactam – the «new player» in a battle against multiresistant pathogens

Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 20(4):354-361

​ Golub A.V., Kozlov R.S.
10.36488/cmac.2018.4.354-361
ceftolozane/tazobactam antimicrobial resistance Pseudomonas aeruginosa Enterobacterales intra-abdominal infections peritonitis urinary tract infections pyelonephritis
Section
Antimicrobials
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 20(4):354-361

Abstract

Ceftolozane/tazobactam is a new combined antibacterial agent for the treatment of infections caused by gram-negative microorganisms, P. aeruginosa in particular, including strains resistant to other clinically available antimicrobials. In this paper we reviewed the data on antimicrobial activity, pharmacokinetics, clinical efficacy and safety of ceftolozane/tazobactam, as well as its potential role for the treatment of complicated intra-abdominal infections and urinary tract infections.

Alexey V. Golub

Smolensk State Medical University, Smolensk, Russia

Roman S. Kozlov

Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, Smolensk, Russia

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