urinary tract infections

Objective. To study in vitro activity of antimicrobials against clinical isolates obtained from patients with community-acquired urinary tract infections (UTIs) in various regions of Russia in 2023. Materials and Methods. The study included 1098 isolates obtained from the urine of children and adults of both sexes of all age groups with acute and exacerbation of recurrent community-acquired UTIs, including pregnant women with asymptomatic bacteriuria. Isolates were collected in 29 centers in 21 cities of Russia in 2023 as part of a multicenter prospective epidemiological study of the dynamics of antibiotic resistance of pathogens causing community-acquired UTIs in different subsets of patients («DARMIS-2023»).

Piperacillin/tazobactam is a well-known β-lactam antibiotic that has been used in clinical practice since 1993. The review presents the clinical and pharmacological characteristics of piperacillin-tazobactam, the results of clinical studies and …

Objective. To compare results of microbiological examination obtained on rapid automated system with semiquantitative plate culture to assess possibility and necessity of using the system in urine examination. Materials and Methods. The study included 231 urine samples collected from February to July 2023 from patients at Lomonosov Moscow State University Medical Research and Educational Center. The samples were cultured according to the standards of urine microbiological examination using chromogenic media and using an automatic HB&L system (Alifax, Italy) for 4 h.

The title of this review “War and peace” is not accidental and the analogies with a well-known literary masterpiece have absolutely justified ground. As in the case of Lev Tolstoy’s novel this title has a profound philosophical meaning, although at …

Cephalosporins are one of the most commonly used antimicrobials for the treatment of variety of bacterial infections. Prudent use of the third-generation cephalosporins is important for the control of spread of cephalosporin-resistant Gram-negative …

The recently approved cefotaxime/sulbactam, combination of third-generation cephalosporin (cefotaxime) and beta-lactamase inhibitor (sulbactam), can combat resistance mechanisms associated with the production of serine beta-lactamases, including some …

Ceftolozane/tazobactam is a new combined antibacterial agent for the treatment of infections caused by gram-negative microorganisms, P. aeruginosa in particular, including strains resistant to other clinically available antimicrobials. In this paper …

This paper presents current issues with the oral thirdgeneration cephalosporins in outpatient clinical practice. These data are based on the principles of appropriate antimicrobial therapy, national antimicrobial susceptibility data, and …

«Respiratory» fluoroquinolones, unlike previous generations, have higher activity against Gram-positive pathogens causing important infections in humans. Broad antimicrobial spectrum, ability to overwhelm some bacterial resistance mechanisms, absence …

Objective. Objectives. To investigate etiology and susceptibility of pathogens causing community-acquired urinary tract infections (UTIs) in different regions of Russia in various patients’ subsets to the most clinically used antimicrobials. Materials and Methods. A total of 903 uropathogens isolated from urine samples of children and adults of all age groups with acute (and recurrence of chronic) community-acquired UTIs, including pregnant women with asymptomatic bacteriuria were collected in 26 centers of 18 cities in Russia during 2010–2011 and included in the «DARMIS» study.