Clinical Microbiology and Antimicrobial Chemotherapy. 2013; 15(1):47-55
«Respiratory» fluoroquinolones, unlike previous generations, have higher activity against Gram-positive pathogens causing important infections in humans. Broad antimicrobial spectrum, ability to overwhelm some bacterial resistance mechanisms, absence of cross-resistance, and unique pharmacokinetic properties make «respiratory» fluoroquinolones the drugs of choice in the treatment of different infections in outpatient and hospital settings. This review presents the results of observational studies and well-designed clinical trials demonstrating efficacy of levofloxacin in the treatment of patients with respiratory tract infections, urinary tract infections, skin and soft tissue infections, and intra-abdominal infections.