Antimicrobials

On March 28, 2026, an expert summit titled «Antibiotics and Probiotics: Old Challenges and New Solutions,» organized by Sandoz, took place in Moscow. The summit brought together more than 50 experts in the fields of antibacterial therapy, …

Biapenem, in combination with polymyxin and/or tigecycline, has promising potential in the treatment of severe infections in children, including infections caused by some difficult to treat resistant pathogens. However, biapenem is currently approved …

This review presents current data on the microbiological activity, efficacy, and safety of the fifth-generation semisynthetic cephalosporin ceftobiprole in modern clinical practice. While literature reviews on this topic have been previously …

Objective. To study pharmacokinetics (PK) and develop a pharmacokinetic/pharmacodynamic (PK/PD) model of linezolid for preterm infants, based on therapeutic drug monitoring (TDM) data. Materials and Methods. The PK/PD analysis included data from therapeutic drug monitoring (TDM) of 24 premature infants, taking into account the repeated TDM procedure – a total of 27 occasions and 54 measurements of linezolid concentration. Quantitative determination of linezolid concentrations in the blood plasma of patients was carried out using the analytical method of measurement by HPLC-UV previously developed on the basis of the educational and scientific laboratory for the study of drug safety at the Department of General and Clinical Pharmacology of the RUDN University in the City Clinical Hospital No.

As part of the VIII scientific and practical conference with international participation, «Modern Challenges in Infection Therapy (SVETI 2026),» held in Moscow on March 27, 2026, a roundtable discussion entitled «Pneumonia. From …

Objective. Development and validation of a suite of mathematical models to predict national-level antimicrobial resistance (AMR) trends by integrating antimicrobial consumption (AMC) and current AMR data. Materials and Methods. Data on systemic antimicrobial consumption across 82 regions of the Russian Federation (2008–2022; source: IQVIA) and AMR levels (2013–2022; source: AMRmap.ru) were analyzed. The workflow included regional name normalization, exclusion of antimicrobials with low clinical relevance, calculation of moving averages (3–10 years) for AMR parameters, and AMC quantification in Defined Daily Doses (DDD).

Objective. To conduct a comparative in vitro analysis of the activity of biapenem and meropenem, as well as to evaluate the efficacy of their combinations with colistin against clinical isolates of Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa producing carbapenemases of different molecular classes. Materials and Methods. The study included 197 carbapenem-resistant clinical isolates of K. pneumoniae, A. baumannii and P. aeruginosa with a phenotype of multidrug (MDR) and extensively drug (XDR) resistance.

The annual increase in probiotic usage is nothing short of phenomenal. Given the large volume of information on beneficial microorganisms, it can be challenging for clinicians to select the most suitable probiotic for a patient. This article provides …

On May 29, 2025, a meeting of the Expert Council «Cefixime (a modern oral 3rd generation cephalosporin from Sandoz) and its place in clinical practice» was held. The meeting included representatives of leading Russian research and …

Objective. To study pharmacodynamics of meropenem alone and in combination with avibactam in an in vitro dynamic model; to evaluate effectiveness of meropenem against K. pneumoniae strains producing and not producing carbapenemases; to study impact of bacterial inoculum on meropenem activity and its effects. Materials and Methods. K. pneumoniae producing KPC and OXA-48 carbapenemases and non-producing strains were exposed to meropenem or its combination with avibactam (carbapenemase-producing strains only) in a modified in vitro hollow-fiber infection model (pneumoniae) simulating human pharmacokinetics of drugs administrated thrice daily for 5 days.