Clinical Microbiology and Antimicrobial Chemotherapy. 2012; 14(4):280-302
Objectives. To investigate etiology and susceptibility of pathogens causing community-acquired urinary tract infections (UTIs) in different regions of Russia in various patients’ subsets to the most clinically used antimicrobials.
A total of 903 uropathogens isolated from urine samples of children and adults of all age groups with acute (and recurrence of chronic) community-acquired UTIs, including pregnant women with asymptomatic bacteriuria were collected in 26 centers of 18 cities in Russia during 2010–2011 and included in the «DARMIS» study.
Among the identified microorganisms the most prevalent uropathogens were Enterobacteriaceae spp. (85.4%) and E. coli (65.1%). The most active oral drugs against E. coli were fosfomycin (98.3%), nitrofurantoin (97.8%) and ceftibuten (93.4%). Furazidin also demonstrated a high rate of activity against E. coli strains. Out of oral antibiotics only fosfomycin was active against more than 90% of all Enterobacteriaceae spp. strains (91.8%), whereas nitrofurantoin and ceftibuten demonstrated activity against 85.6% and 89.5% of strains respectively. Out of parenteral drugs the most active against E. coli were meropenem and imipenem with totally no resistant strains observed. Also high in vitro activity demonstrated ertapenem (99.8%), amikacin (97.9%), piperacillin/tazobactam (93.0%), gentamicin (90.1%) and III–IV generation cephalosporins. Carbapenems were the most active parenteral antimicrobials against all Enterobacteriaceae spp. strains as well.
Susceptibility results shown in «DARMIS» study enable the evaluation of appropriate antimicrobial choice for empirical treatment of community-acquired UTI in Russia.