antimicrobial resistance

Objective. To assess the categorization of antimicrobial susceptibility testing results using aggregated data from microbiology laboratories in the Russian Federation for 2023 and 2024, considering interpretation standards, their versions, microorganisms, and federal districts. Materials and Methods. A retrospective descriptive study of aggregated microbiology laboratory data for 2023 and 2024 was performed. Data from 494 laboratories in 2023 and 520 laboratories in 2024 were included. We assessed the use and recency of interpretation standards, the proportion of errors/inaccuracies among tested results, and their distribution by type, microorganism, federal district, and standard recency group.

Biapenem, in combination with polymyxin and/or tigecycline, has promising potential in the treatment of severe infections in children, including infections caused by some difficult to treat resistant pathogens. However, biapenem is currently approved …

Objective. To study structure of pathogens of community-acquired urinary tract infections (UTI) in children and adolescents under 18 years of age subpopulation of the Krasnoyarsk region as well as the activity of antimicrobials against the leading pathogen in order to optimize local empirical therapy of UTI. Materials and Methods. A total of 298 urine cultures were analyzed (164 in 2023 and 134 – in 2024). The urinalyses were obtained from children and adolescents with community-acquired UTI who hospitalized to the Krasnoyarsk Regional Clinical Center for Maternal and Child Health in 2023–2024.

Antimicrobial resistance poses a significant global threat to healthcare systems worldwide. The high cost and short lifespan of new antibiotics due to the rapid evolution of resistance exacerbate this crisis, prompting exploration of diverse …

Objective. Creation and evaluation of the effectiveness of an integrated system for automatic validation of microbiological reports and monitoring of antimicrobial resistance (AMR) on real time at the regional level within the Yamalo-Nenets Autonomous Okrug (YNAO). Materials and Methods. The prospective study was conducted from October 2023 to June 2025, based on the Medical Information and Analytical Center and five largest hospitals in the YNAO. The study design included a comparative analysis of AMR monitoring status before and after the implementation of the digital platform.

Objective. To determine the population structure of clinical P. aeruginosa isolates recovered from hospitals in different regions of Russia and to assess the role of high-risk clones in the dissemination of carbapenemases and carbapenem resistance. Materials and Methods. The study included consecutive, non-duplicate clinical isolates of P. aeruginosa (N = 1379) obtained from 55 hospitals across 30 Russian cities over a 24-month period. Species identification was performed using MALDI-TOF mass-spectrometry.

Objective. To evaluate level of knowledge, attitudes, and practices (KAP) concerning sepsis and antimicrobial resistance (AMR) among medical students in the Russian Federation. Materials and Methods. A multicenter, cross-sectional survey was conducted among students from six medical universities using a validated questionnaire (Cronbach’s alpha: 0.74) developed based on the Knowledge, Attitudes, and Practices (KAP) model. Results. The study included 1052 respondents, comprising 315 (29.9%) males and 737 (70.1%) females, with a median age of 22 [21; 24] years.

Objective. To implement a closed digital loop for continuous antimicrobial resistance (AMR) surveillance based on validated microbiological diagnostic results. Materials and Methods. A prospective study was conducted at the Federal State Autonomous Institution «National Medical Research Center for Treatment and Rehabilitation» of the Ministry of Health of the Russian Federation from May 2024 to September 2025. An audit of the initial state of processes, a SWOT analysis, software restructuring, data flow optimization and standardization of diagnostic methods in accordance with EUCAST recommendations were performed.

The problem of antimicrobial resistance represents one of the most urgent and complex problems of modern healthcare. The measures that are being taken today to control antimicrobial resistance, however, cannot be considered satisfactory, and we are …

Objective. To study susceptibility of clinical Bacteroides spp. and Clostridium perfringens isolates to antimicrobial agents across different regions of the Russian Federation and to identify regional patterns of antimicrobial resistance. Materials and Methods. The study included 1,685 isolates of obligate anaerobic bacteria belonging to 107 species, isolated from patients in 60 regions of the Russian Federation during period from January 2023 to December 2024. Among them, 144 C. perfringens isolates from 37 regions, and 370 Bacteroides spp.