Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(2):153-166
Treatment of intra-abdominal infections (IAI) is а significant problem in surgery. Taking into consideration the clinical practice in Russia, this paper presents an analysis of guidelines on antimicrobial therapy for IAI, developed by Surgical Infection Society and published in 2002. The main issues of antimicrobial therapy of IAI, such as patient selection and optimal duration of antimicrobial therapy are considered. Recommended their antimicrobial agents and combinations for treatment of IAI, which were shown in large number of prospective controlled trials to have high clinical efficacy, are listed. Risk factors for treatment failure and death in patients with IAI are identified. Choice of antimicrobials in higher-risk patients is provided as well. Relevant areas for future investigations, focusing on improving antimicrobial therapy of IAI, are presented.