Antimicrobial Therapy of Complicated Intra-abdominal Infections: What are the Success Determinants?

Clinical Microbiology and Antimicrobial Chemotherapy. 2011; 13(2):158-162

Journal article


Successful outcome of complicated intra-abdominal infections (peritonitis) is determined by two key factors – surgical control of infection site and appropriate and timely antimicrobial therapy. Over the years choice of high antimicrobials for the treatment of communityacquired peritonitis had previously not a problem because of susceptibility of pathogens to most recommended antimicrobial agents. However, a global trend for community-acquired infections, particularly peritonitis, to be caused by resistant pathogens is observed and requires update of standards for empiric antimicrobial therapy of these infections. A high incidence of extended spectrum beta-lactamase production among Enterobacteriaceae makes carbapenems without anti-pseudomonal activity drugs of choice in the treatment of community-acquired complicated IAI.

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