Diseases and Pathogens

Over the last years, influence of the human microbiome on the emergence of non-infectious chronic diseases including psoriasis has become a popular research field. A significant goal is to get an answer to the following question: are changes in the …

Objective. To evaluate the results of implementing the AMRcf and AMRcloud platforms for microbiological surveillance studies of patients with cystic fibrosis (CF) into the routine practice of a microbiological laboratory. Materials and Methods. The study was performed on the basis of the Department of Microbiology of the Clinical diagnostic laboratory of the Clinics of the Samara State Medical University. To perform the study, the following computer programs were introduced into routine practice: AMRcf (online microbiological registry for CF patients) and AMRcloud (online platform for analysis of collected data on antibiotic resistance).

Objective. To compare the species diversity of non-tuberculous mycobacteria (NTM) isolated from patients of phthisiopulmonary institutions in 2018–2019 (“pre-Covid” period) and in 2020–2023 (during the COVID-19 pandemic). Materials and Methods. We identified 937 clinical isolates of NTM, isolated from patients undergoing differential diagnosis of tuberculosis and other respiratory diseases at The National Medical Research Center o Phthisiopulmonology and Infectious Diseases under the Ministry of Health of the Russian Federation (NMRC PhPI) and in other phthisiopulmonological institutions of the Russian Federation in 2018–2019 (“pre-Covid” period, n = 217) and in 2020–2023 (during the COVID-19 pandemic, n = 720).

Objective. To analyze the profile of bacterial pathogens in patients with extremities wounds resulting from mine-blast injuries, and their susceptibility to antibacterial drugs. Materials and Methods. The prospective observational study enrolled 234 patients who suffered injuries to the lower and/or upper extremities in the period from 4 to 36 days (mean 14.9 ± 7.4 days) before admission to the hospital. All study participants were men. The age of study patients ranged from 19 to 59 years (mean 35.

Objective. Seroyping of the Streptococcus pneumoniae strains obtained from patients with invasive and non-invasive forms of pneumococcal infection circulating in Russia using whole-genome sequencing. Materials and Methods. The 144 invasive and 90 non-invasive S. pneumoniae strains isolated in 2002– 2023 during the multicenter epidemiological study «PEGASus» were investigated. Real-time PCR and whole-genome sequencing were used to determine serotypes. The 16 serotyping targets were examined by PCR technique. Whole-genome sequencing was performed on the Illumina equipment.

Monkeypox (mpox) is a particularly dangerous zoonotic infectious disease, the causative agent of which belongs to the numerous family Poxviridae, subfamily Chordopoxvirinae, genus Orthopoxvirus and belongs to the I pathogenicity group; genetically …

Objective. In 2023–2014, a significant increase in the incidence of pneumonia caused by M. pneumoniae has been reported in Russia and China. Despite being one of the primary causative agents of community-acquired lower respiratory tract infections in children, due to the difficulties in obtaining a culture of this pathogen, the amount of genomic data on M. pneumoniae is currently extremely limited, with fewer than 300 genomic sequences available, of which only 79 are complete.

Breast surgery is a broad field that includes both surgical treatment of breast diseases and various variants of reconstructive and plastic surgeries for breast correction. Despite the fact that according to the accepted classification breast …

Since the development of microbiology as a science, the identification, systematics and classification of microorganisms have been carried out based on the study of phenotypic characteristics. In the second half of the 20th century, after the …

Syphilis belongs to the category of socially significant sexually transmitted infections, the control of which is one of the priorities in global health. The beginning of the twentieth century was marked by the discovery of the causative agent of …