Diseases and Pathogens

Objective. To determine frequency and spectrum of cytomegalovirus (CMV) resistance mutations to antiviral drugs in immunocompromised children. To study clinical course of resistant CMV infection in this patient population. Materials and Methods. This prospective study included 120 patients of the Dmitry Rogachev NMRC PHOI who mainly were recipients of allogeneic hematopoietic stem cell transplantation (HSCT) with confirmed CMV infection (median age – 8.9 years). The study inclusion criterion was the possible development of CMV drug resistance.

Modern diagnosis of syphilis, despite the widespread use of serological methods, has several limitations, including insufficient specificity of non-treponemal tests and challenges in differentiating infection stages. This article reviews the …

Klebsiella pneumoniae is one of the most common pathogens causing community-acquired and nosocomial infections in hospitalized patients. Among the two known pathotypes, hypervirulent (hvKp) has become a matter of serious concern, as such isolates can …

This article analyzes epidemiological, pathogenetic, and clinical features of respiratory syncytial virus (RSV) infection in adults. It provides a review of current data on medical and healthcare burden of RSV in various regions worldwide, actual …

Objective. To investigate the genetic diversity of the Russian population of C. trachomatis. Materials and Methods. We analyzed 42 clinical isolates of C. trachomatis obtained in 2024. MLST typing was performed using the Uppsala scheme (genes CT058, CT144, CT172, hctB, pbpB) and sequencing of the ompA gene for serotype determination. Results. 8 serotypes (E – 50.0% predominates) and 26 sequence types (ST) were identified, including 8 new ones (19.0% of isolates).

In modern literature, there is insufficient information on the composition of the conjunctival microbiota in children under 1 year of age, and information on its composition in premature infants is virtually absent. Analysis of conjunctival …

Acute liver failure (ALF) is a rapidly developing condition with a broad etiologic factor and incompletely understood mechanisms of pathogenesis. Timely identification of the cause and rapid initiation of etiologic treatment, detection, prevention …

Invasive aspergillosis is a serious disease that can occur in organ transplant recipients. Most often, this complication develops in recipients of lung, heart, and liver transplants. Kidney transplant recipients are less likely to develop the …

Objective. To characterize spectrum of S. pneumoniae serotypes isolated from patients with invasive pneumococcal infection in the Russian Federation. Materials and Methods. The serotype identification of 93 S. pneumoniae isolates obtained from blood and cerebrospinal fluid of patients with various forms of invasive pneumococcal disease was performed using whole-genome sequencing. PCV-13, PCV-15, PCV-20 and PPV-23 coverage of circulated serotypes was estimated using descriptive statistics. Results. The study included 93 S.

Objective. To assess prevalence, etiology, antimicrobial prescribing practices and treatment outcomes of infections in intensive care units in Russia. Materials and Methods. A two-stage (the first stage – October 18, 2022, the second stage – November 18, 2022) multicenter prospective one-day observational study involved 111 intensive care units (ICUs) of 67 centers from 25 cities of the Russian Federation. Each patient was included in the study only once. Data from the medical records of all patients in the ICU on the day of the study were entered by the attending physician into a single electronic individual case report form.