Diseases and Pathogens

This literature review summarizes actual data on the use of anti-infective drugs in the treatment of brain abscesses, in particular, otorinosnusogenic ones. Mainly the largest publications over the last decade concerning this issue were analyzed. The …

The article analyzes statistical data on the incidence of diphtheria in the Russia at the end of the XX and the beginning of XXI century, provides absolute and relative intensive incidence rates in the country level, examines the patterns of the …

This review provides the characteristics of representatives of the Weissella genus, including W. confusa, W. cibaria, and W. viridescens. The morphological, cultural, biochemical serological properties of these microorganisms belonging to the genus …

Objective. To determine role of ferritin (FT), procalcitonin (PCT) and their ratio (FT/PCT) in the differential diagnosis of viral lung injury and bacterial community-acquired pneumonia (CAP). Materials and Methods. A prospective multicenter study included adult patients with CAP hospitalized in multidisciplinary hospitals from July to November 2023. All patients had their PCT and FT levels determined in addition to the standard examination protocol. Etiological diagnostics included microbiological examination of a respiratory sample and blood (in severe cases), rapid tests for pneumococcal and legionella antigenuria, and molecular testing of respiratory samples to detect DNA/RNA of the most common respiratory viruses and difficult-to-culture or non-cultivate bacterial pathogens.

Antimicrobial therapy is an essential part of treatment of urinary tract infections, often being the only etiological and pathogenetic component of it. At the same time, the rationality of choosing an antimicrobial depends both on the sensitivity of …

Over the last years, influence of the human microbiome on the emergence of non-infectious chronic diseases including psoriasis has become a popular research field. A significant goal is to get an answer to the following question: are changes in the …

Objective. To evaluate the results of implementing the AMRcf and AMRcloud platforms for microbiological surveillance studies of patients with cystic fibrosis (CF) into the routine practice of a microbiological laboratory. Materials and Methods. The study was performed on the basis of the Department of Microbiology of the Clinical diagnostic laboratory of the Clinics of the Samara State Medical University. To perform the study, the following computer programs were introduced into routine practice: AMRcf (online microbiological registry for CF patients) and AMRcloud (online platform for analysis of collected data on antibiotic resistance).

Objective. To compare the species diversity of non-tuberculous mycobacteria (NTM) isolated from patients of phthisiopulmonary institutions in 2018–2019 (“pre-Covid” period) and in 2020–2023 (during the COVID-19 pandemic). Materials and Methods. We identified 937 clinical isolates of NTM, isolated from patients undergoing differential diagnosis of tuberculosis and other respiratory diseases at The National Medical Research Center o Phthisiopulmonology and Infectious Diseases under the Ministry of Health of the Russian Federation (NMRC PhPI) and in other phthisiopulmonological institutions of the Russian Federation in 2018–2019 (“pre-Covid” period, n = 217) and in 2020–2023 (during the COVID-19 pandemic, n = 720).

Objective. To analyze the profile of bacterial pathogens in patients with extremities wounds resulting from mine-blast injuries, and their susceptibility to antibacterial drugs. Materials and Methods. The prospective observational study enrolled 234 patients who suffered injuries to the lower and/or upper extremities in the period from 4 to 36 days (mean 14.9 ± 7.4 days) before admission to the hospital. All study participants were men. The age of study patients ranged from 19 to 59 years (mean 35.

Objective. Seroyping of the Streptococcus pneumoniae strains obtained from patients with invasive and non-invasive forms of pneumococcal infection circulating in Russia using whole-genome sequencing. Materials and Methods. The 144 invasive and 90 non-invasive S. pneumoniae strains isolated in 2002– 2023 during the multicenter epidemiological study «PEGASus» were investigated. Real-time PCR and whole-genome sequencing were used to determine serotypes. The 16 serotyping targets were examined by PCR technique. Whole-genome sequencing was performed on the Illumina equipment.