Diseases and Pathogens | CMAC

Diseases and Pathogens

Systematic review of seroprevalence of markers of hepatitis B, C and HIV among oncohematological patients

The purpose of systematic review was to assess the incidence of blood-borne infections in oncohematological patients in the period from 1980 to 2020 in different countries of the world, including in main oncohematological clinical groups of patients, …

Phylogeny and antibiotic resistance of Treponema pallidum subsp. pallidum

The species Treponema pallidum includes 4 subspecies. According to the bioinformatic analysis, the syphilis pathogen T. pallidum subsp. pallidum was probably separated from the causative agents of yaws, bejel, and pinta more than 800 years ago. Its …

Genomic characterization of oxacillin-susceptible mecA-positive Staphylococcus aureus ST59

Objective. To characterize the genomes of oxacillin-susceptible mecA-positive Staphylococcus aureus ST59 isolated in St. Petersburg. Materials and Methods. Nine oxacillin-susceptible mecA-positive of S. aureus isolates (OS-MRSA) of ST59 were included in the study. The isolates were obtained from children who showed no clinical signs of staphylococcal infections during nasal screening of S. aureus in St. Petersburg in 2018–2019. One isolate was obtained from an adult patient with skin and soft tissue infection (SSTI).

Fusobacterium nucleatum: from a classic periodontal pathogen to a complete participant of carcinogenesis

Fusobacterium nucleatum is a component of the oral microflora, and in clinical practice it is associated primarily with periodontal diseases. Since 2011, the scientific community has confirmed the association of F. nucleatum with colorectal cancer …

Current approaches and prospects for the development of laboratory diagnosis of measles

Measles virus causes an acute infectious disease with high contagiousness. It is possible to limit the spread of measles virus only with a sufficiently wide coverage of the population by vaccination. Despite the success of measles elimination …

Fecal microbiota transplantation as a treatment option for patients with recurrent Clostridioides difficile-associated diarrhea

This paper provides a review of the largest studies (over the period of 2017 to 2022) on the use of fecal microbiota transplantation (FMT) for the treatment of patients with recurrent *Clostridioides difficile*associated diarrhea (CDAD), including …

С. difficile infection: clinical and pharmacoeconomic assessment of treatment regimens in antibiotic-associated diarrhea

This paper provides a review of the largest studies (over the period of 2017 to 2022) on cost-effectiveness analysis of the recommended treatment algorithms for Clostridioides difficile infection in patients with antibiotic-associated diarrhea (AAD), …

Invasive aspergillosis in patients with COVID-19 in intensive care units: results of a multicenter study

Objective. To study risk factors, clinical and radiological features and effectiveness of the treatment of invasive aspergillosis (IA) in adult patients with COVID-19 (COVID-IA) in intensive care units (ICU). Materials and Methods. A total of 60 patients with COVID-IA treated in ICU (median age 62 years, male – 58%) were included in this multicenter prospective study. The comparison group included 34 patients with COVID-IA outside the ICU (median age 62 years, male – 68%).

Temperate enterococcal bacteriophages: genetic features and practical application

Temperate bacteriophages are of interest as carriers and vectors of pathogenicity factors that determine an epidemic potential of opportunistic bacteria as well as biotechnology objects. This review describes studies of temperate bacteriophages …

Microbiota in the pathogenesis of COPD and its impact on the course of the disease

Chronic obstructive pulmonary disease (COPD) is a serious problem for global health. Infectious agents play a main role in the development of COPD exacerbations. Bacterial colonization of the lower respiratory tract is common in patients with stable …