Clinical Microbiology and Antimicrobial Chemotherapy. 2010; 12(2):127-145
The emergence and spread of resistance to multiple classes of antimicrobials is a growing threat, especially in microorganisms causing severe nosocomial infections in hospital settings. Tigecycline, the first in a new class of antimicrobials (glycylcyclines), takes a special place among newly introduced antimicrobial agents. Tigecycline is active against many Gram-positive and Gram-negative pathogens, including strains resistant to other classes of antimicrobials. This paper represents main data on spectrum of activity, pharmacokinetics and pharmacodynamics, clinical efficacy, safety, and tolerability of tigecycline and, therefore, its role in a current clinical practice.