Тигециклин: перспективы применения в клинической практике

Клиническая Микробиология и Антимикробная Химиотерапия. 2010; 12(2):127-145

​ Андреева И.В., Стецюк О.У., Козлов Р.С.
тигециклин глицилциклины антибиотикотерапия резистентность
Раздел
Антимикробные препараты
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2010; 12(2):127-145

Аннотация

Проблема резистентности микроорганизмов ко многим классам антимикробных препаратов (АМП) приобретает все более угрожающий характер, особенно среди возбудителей тяжелых нозокомиальных инфекций в стационаре. Среди новых АМП, появившихся в клинической практике, особое место занимает тигециклин — первый и единственный глицилциклин, активный в отношении многих грамположительных и грамотрицательных микроорганизмов, включая штаммы, обладающие механизмами резистентности к другим классам антибиотиков. В данном обзоре представлены основные сведения, касающиеся антибактериальной активности, фармакокинетики и фармакодинамики, терапевтической эффективности, безопасности и переносимости тигециклина, а также рассмотрено его место в современной клинической практике.

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