resistance

According to the mutant selection window (MSW) hypothesis resistant mutants are selected at antibiotic concentrations above the MIC but below the mutant prevention concentration (MPC). There are contradictory reports on the relationships between MIC- …

This article presents the results of the study to determine etiology and antimicrobial susceptibility in diabetic foot infections (DFI). A total of 288 isolates were obtained from patients with confirmed DFI by fine-needle aspiration/biopsy during …

The carbapenems are class of beta-lactam antibiotics with exceptionally wide spectrum of activity, beneficial pharmacokinetic parameters and low toxicity as well. Such agents as imipenem and meropenem have already been succesfully used for a long …

Invasive candidiasis is a common nosocomial infection with high attributable mortality among ICU patients. This study was performed to determine isolation rate of Candida spp. in cardiac surgical ICUs during the period of 2001–2007 and to assess …

The objectives of this study were to investigate etiology of acute bacterial rhinosinusitis (ABR) in young soldiers, to determine susceptibility to different antimicrobial agents and to assess clinical efficacy of antimicrobial therapy in ABR. …

Objective. To determine in vitro activity of antimicrobials against S. aureus isolated from ICU patients in different regions of Russia. Materials and Methods. A total of 998 clinical strains of S.aureus isolated in 2004–2005 from 998 patients hospitalized in ICU of 32 medical institutions in different parts of Russia. Susceptibility to 16 antimicrobials was determined by agar dilution method in accordance with CLSI recommendations. Results. The prevalence of MRSA among tested strains was 49.

Objective. To determine in vitro activity of antimicrobials against S. aureus isolated from ICU patients in different regions of Russia. Materials and Methods. A total of 998 clinical strains of S.aureus isolated in 2004-2005 from 998 patients hospitalized in ICU of 32 medical institutions in different parts of Russia. Susceptibility to 16 antimicrobials was determined by agar dilution method in accordance with CLSI recommendations. Results. The prevalence of MRSA among tested strains was 49.

In vitro susceptibility study of 3042 gram-negative nosocomial strains isolated during 2002-04 from patients with nosocomial infections in 34 Russian ICUs was performed (in the framework «RESORT» survey). The following antibiotics were tested: …

The carbapenems are one of the most important classes of antimicrobial agents with an exceptionally broad spectrum of in vitro activity in association with low toxicity and beneficial pharmacokinetic parameters. Spectrum of activity of imipenem, …

To study the hypothesis of the mutant selection window (MSW) in a pharmacodynamic context, the susceptibility of a clinical isolate of methicillin-resistant Stap. hylococcus aureus exposed to moxifloxacin (MOX), levofloxacin (LEV) and ciprofloxacin …