Clinical Microbiology and Antimicrobial Chemotherapy. 2009; 11(1):14-21
The objectives of this study were to investigate etiology of acute bacterial rhinosinusitis (ABR) in young soldiers, to determine susceptibility to different antimicrobial agents and to assess clinical efficacy of antimicrobial therapy in ABR. Retrospective analysis of therapy in patients with ABR in the ENT unit (421st Military Hospital of the Ministry of Defense) during the period of 2004–2006 was also performed. A total of 122 patients (age: 16-30 years) with nonsevere ABR and duration of symptoms >7 days were enrolled in the study. Clinical specimens for culture were obtained by maxillary sinus aspiration and frontal sinus trephination. Culture and susceptibility testing were performed according to CLSI standards (2007). Microbiological diagnosis was determined in 56% (68⁄122) of patients. The most common pathogens of ABR were non-typing strains of H. influenzae (32%) and S. pneumoniae (19%). All H. influenzae and pneumococci isolates were susceptible to amoxicillin, levofloxacin, and erythromycin. Clinical efficacy of amoxicillin was 100%; no adverse events were reported. In conclusion, results of this study demonstrated role of H. influenzae and S. pneumoniae as leading causes of ABR in young soldiers as well as high clinical efficacy and safety of amoxicillin in that patient population.