Haemophilus influenzae

Objective. To determine in vitro activity of oral III generation cephalosporin cefpodoxime against clinical isolates of Haemophilus influenzae, Streptococcus pneumoniae and Streptococcus pyogenes isolated from patients with community-acquired respiratory tract infections in different regions of the Russian Federation. Materials and Methods. The study included isolates of bacterial pathogens of community-acquired respiratory tract infections isolated from outpatients and hospitalized patients in different regions of the Russian Federation. A total of 558 isolates were included in the study, including 184 isolates of H.

Objective. To determine in vitro activity of thiamphenicol and other clinically available antimicrobials against clinical isolates of Haemophilus influenzae, Streptococcus pneumoniae and Streptococcus pyogenes. Materials and Methods. We included in the study 875 clinical isolates from 20 Russian cities during 2018–2019. Among tested strains, 126 were H. influenzae, 389 – S. pneumoniae, 360 – S. pyogenes. Antimicrobial susceptibility testing was performed using broth microdilution method according to ISO 20776-1:2006. AST results were interpreted according to EUCAST v.

Objective. To evaluate antimicrobial resistance patterns of clinical Haemophilus influenzae isolates from different regions of Russia during 2014–2017. Materials and Methods. We included in the study 185 clinical H. influenzae isolates from 13 Russian cities. Susceptibility testing was performed by reference broth microdilution method (ISO 207761:2006). Susceptibility testing results were interpreted using EUCAST v. 10.0 breakpoints. Results. H. influenzae isolates were highly susceptible to all (96.8%-100%) β-lactams tested (amoxicillin/ clavulanate, cefixime, ceftaroline, ceftibuten, cefditoren, ertapenem) with the exception of ampicillin (15.

Objective. To study antimicrobial resistance of Haemophilus influenzae and its trends in different Russian regions over the period of 2004–2009. Materials and Methods. This study included consecutive clinical strains of H. influenzae obtained from patients with different infections (pneumonia, acute otitis media, meningitis, bacteremia, COPD exacerbation, etc.) in Central, Volga, Ural, and Siberian federal districts of Russia over the period of 2004–2009. Susceptibility to 12 antimicrobial agents was determined by broth microdilution method according to the Clinical Laboratory Standards Institute guidelines (CLSI 2013).

The objectives of this study were to investigate etiology of acute bacterial rhinosinusitis (ABR) in young soldiers, to determine susceptibility to different antimicrobial agents and to assess clinical efficacy of antimicrobial therapy in ABR. …

To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. There are two patterns of antimicrobial activity: time-dependent killing and concentration-dependent …

The rates of nasopharyngeal carriage of Haemophilus influenzae and epidemiology of its antimicrobial resistance in healthy children from day-care centers have been investigated. The overall rate of nasopharyngeal H.influenzae carriage was 44%. The …