Clinical Microbiology and Antimicrobial Chemotherapy. 2008; 10(4):333-344
To determine in vitro activity of antimicrobials against S. aureus isolated from ICU patients in different regions of Russia.
A total of 998 clinical strains of S.aureus isolated in 2004–2005 from 998 patients hospitalized in ICU of 32 medical institutions in different parts of Russia. Susceptibility to 16 antimicrobials was determined by agar dilution method in accordance with CLSI recommendations.
The prevalence of MRSA among tested strains was 49.9% and varied from 0 to 83% in different hospitals. The most potent antimicrobials were linezolid, vancomycin and mupirocin to which no resistance was found. The other antimicrobials with low frequency of resistance were fusidic acid and co-trimoxazole (0.4% of intermediate and 3% resistant strains, respectively). Fluoroquinolones have shown low activity. The high rates of resistance were found in to erythromycin (46,8%), gentamicin (45,4%), tetracycline (42,3%), lincomycin (41%) and clindamycin (39,9%).
Linezolid and vancomycin can be used as the drugs of choice for the treatment of S.aureus ICU infections in Russian hospitals. High rates of resistance to macrolides, lyncosamides, β-lactams, tetracycline and aminiglicosides advise not to use these antimicrobials for empiric therapy of S.aureus infections in ICU.