Antimicrobial Resistance Patterns of Gram-negative Nosocomial Pathogens in Russian ICUs

Clinical Microbiology and Antimicrobial Chemotherapy. 2008; 10(2):163-179

Journal article


In vitro susceptibility study of 3042 gram-negative nosocomial strains isolated during 2002-04 from patients with nosocomial infections in 34 Russian ICUs was performed (in the framework «RESORT» survey). The following antibiotics were tested: amikacin, amoxicillin/clavulanic acid, cefepime, cefoperazone, cefoperazone/sulbactam, cefotaxime, cefotaxime/clavulanic acid, ceftazidime, ceftazidime/clavulanic acid,ceftriaxone, ciprofloxacin, ertapenem, gentamicin, imipenem, levofloxacin, meropenem, moxifloxacin, piperacillin, piperacillin/tazobactam, polymyxin B (for Pseudomonas aeruginosa), ticarcillin/clavulanate. The most common pathogens were P. aeruginosa (34,6%), Acinetobacter baumannii (15,1%), Klebsiella pneumoniae (13,8%), Esherichia coli (12,8%). P. aeruginosa displayed high level resistance to all agents tested except polymyxin B (5,8% unsusceptible strains). Cefoperazone / sulbactam, imipenem and meropenem showed excellent activity against A. baumannii with 2.2%, 2.2% and 3.5% unsusceptible strains, respectively. Imipenem and meropenem retain their high activity against nosocomial K. pneumoniae and E. coli: all strains were susceptible to these agents. Only 2.6% K. pneumoniae and 0.5% E. coli were unsusceptible to ertapenem. High levels of ESBL production were found in K. pneumoniae and E. coli (81.4% and 49.7%, respectively).

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