resistance

Clinical Perspectives of Tigecycline

The emergence and spread of resistance to multiple classes of antimicrobials is a growing threat, especially in microorganisms causing severe nosocomial infections in hospital settings. Tigecycline, the first in a new class of antimicrobials …

Hospital-Acquired Pneumonia in Trauma Patients: Results of Prospective Observational Study

Objective. To study prospectively clinical course of hospital-acquired pneumonia (HAP), mortality, and risk factors for poor outcome as well as etiology and antibiotic resistance of HAP in trauma patients; to assess antimicrobial therapy in patients with head trauma and orthopedic trauma in Smolensk Clinical Hospital of Emergency Medical Care. Materials and Methods. A prospective observational study in 96 patients with head trauma or orthopedic trauma and concurrent HAP, confirmed by clinical examination, chest X-ray, and Clinical Pulmonary Infection Scale (CPIS) score of ≥5.

Etiology and Antimicrobial Resistance of Hospital-acquired and Community-acquired Intra-Abdominal Infections in ICUs of Two Teaching Hospitals

Objective. To investigate the etiology and antimicrobial resistance patterns of aerobic bacterial pathogens in community- and hospital-acquired intra-abdominal infections (IAI) in the ICUs of two teaching hospitals in one particular city. Materials and Methods. A total of 168 patients with peritonitis (122 community-acquired, 46 nosocomial) were included in the study. Susceptibility testing was performed by agar dilution method according to CLSI recommendations. Results. Clinically significant aerobic pathogens were isolated in 61.

Antimicrobial Resistance and Therapy of Salmonella Infections

This review contains brief information on the epidemiology of salmonellosis as well as the modern classification and nomenclature of Salmonella genus. The main mechanisms of antimicrobial resistance in Salmonella and their prevalence are summarized. …

Prediction of Development of Antimicrobial Resistance in In-vitro Dynamic Models of Different Dosage Regiments

According to the mutant selection window (MSW) hypothesis resistant mutants are selected at antibiotic concentrations above the MIC but below the mutant prevention concentration (MPC). There are contradictory reports on the relationships between MIC- …

Etiology of Diabetic Foot Infections and In Vitro Activity of Antimicrobial Agents

This article presents the results of the study to determine etiology and antimicrobial susceptibility in diabetic foot infections (DFI). A total of 288 isolates were obtained from patients with confirmed DFI by fine-needle aspiration/biopsy during …

Ertapenem – a Newer Carbapenem

The carbapenems are class of beta-lactam antibiotics with exceptionally wide spectrum of activity, beneficial pharmacokinetic parameters and low toxicity as well. Such agents as imipenem and meropenem have already been succesfully used for a long …

Fungal Infections Surveillance in Intensive Care Units

Invasive candidiasis is a common nosocomial infection with high attributable mortality among ICU patients. This study was performed to determine isolation rate of Candida spp. in cardiac surgical ICUs during the period of 2001–2007 and to assess …

Acute Bacterial Rhinosinusitis in Young Soldiers: Etiology, Susceptibility and Antimicrobial Therapy

The objectives of this study were to investigate etiology of acute bacterial rhinosinusitis (ABR) in young soldiers, to determine susceptibility to different antimicrobial agents and to assess clinical efficacy of antimicrobial therapy in ABR. …

Epidemiology of Antimicrobial Resistance of S. aureus Isolated from ICU Patients in Russia: Results of Prospective Multicenter Study

Objective. To determine in vitro activity of antimicrobials against S. aureus isolated from ICU patients in different regions of Russia. Materials and Methods. A total of 998 clinical strains of S.aureus isolated in 2004–2005 from 998 patients hospitalized in ICU of 32 medical institutions in different parts of Russia. Susceptibility to 16 antimicrobials was determined by agar dilution method in accordance with CLSI recommendations. Results. The prevalence of MRSA among tested strains was 49.