resistance

Complicated Community-Acquired Urinary Tract Infections in Adult Patients in Russia

Objective. Objectives. To analyze etiology and antimicrobial resistance of pathogens causing complicated community-acquired urinary tract infections (cUTI) in adult patients in different regions of Russia. Materials and Methods. Uropathogens isolated from urine samples of patients of both gender older than 18 years of age with community-acquired UTI were collected in 21 centers of 17 cities in Russia during 2010–2011 and included in the «DARMIS» study. Results. Among the collected 518 strains isolated from adult patients 282 strains (54,4%) were isolated from urine of patients with cUTI.

Carbapenems in the Multidisciplinary Hospital: Some Clinical and Economic Consequences

The changes in carbapenem consumption during 6 consecutive years have been studied in retrospective trial. 88% of carbapenems have been administered in the ICU’s and hematology department. The 3-fold increase of the total consumption during …

Current View on Antimicrobial Therapy of Intra-Abdominal Infections

Currently, treatment of intra-abdominal infections is significantly complicated by increased antimicrobial resistance. Inappropriate antimicrobial therapy is one of the reasons for spread of extended spectrum beta-lactamases (ESBL) both in hospital …

Characteristics of Nosocomial Strains of Acinetobacter spp. in a Trauma Center

Incidence rates of Acinetobacter spp. isolated from tissue specimens and wound samples in patients with severe burns, chronic osteomyelitis, and diabetic foot infections were determined during the 5 years (2008– 2012). Antimicrobial resistance of …

Medical Problems Associated with Bacterial Biofilms

This paper represents a review of currently available data on microbial communities and biofilms as an important clinical problem. Structure and morphology of microbial biofilm as well as stages and mechanisms of its formation, and genes and factors …

Review of Current Guidelines on the Management of Pediatric Patients with Acute Bacterial Rhinosinusitis

Acute bacterial rhinosinusitis (ABRS) is a common disease in pediatric practice, which takes a fifth place among the causes of antimicrobials administration to children. This paper presents a review of current clinical guidelines on the management of …

Prevalence and Molecular Epidemiology of Gram-negative Bacteria Producing Metallo-β-lactamases (MBLs) in Russia, Belarus and Kazakhstan

The prevalence and molecular epidemiology of MBLproducing Gram-negative bacteria have been studied in Russia (1998–2010), Belarus and Kazakhstan (2005– 2010). Analysis of nosocomial strains isolated as part of several multicentre surveillance studies …

Selection of Resistance Associated with the Use of Antimicrobial Agents: Collateral Damage Concept

Collateral damage concept describes an adverse ecological effect associated with the use of antimicrobial agents. The main point is a selection of multidrug-resistant strains and subsequent colonization and infections caused by those microorganisms. …

Ciprofloxacin in Current Clinical Practice

Ciprofloxacin is the most known member of second generation quinolones, which is more active against gram-negative microorganisms and has broad antimicrobial spectrum compared to first generation quinolones. This article presents the main indications …

Clinical Perspectives of Tigecycline

The emergence and spread of resistance to multiple classes of antimicrobials is a growing threat, especially in microorganisms causing severe nosocomial infections in hospital settings. Tigecycline, the first in a new class of antimicrobials …