Mechanisms and regulation of antimicrobial resistance in Pseudomonas aeruginosa

Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(4):308-319

​ Chebotar I.V., Bocharova Yu.A., Mayansky N.A.
Pseudomonas aeruginosa antibiotics resistance beta-lactamases permeability efflux
Section
Antimicrobial Resistance
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(4):308-319

Abstract

Pseudomonas aeruginosa is a dangerous opportunistic pathogen. One of the most negative clinically significant features of P. aeruginosa is associated with the rapid acquisition of antimicrobial resistance. This review provides an analysis of current literature data on genetic mechanisms of resistance of P. aeruginosa to antibiotics. Acquisition of resistance and its regulation are considered. Understanding of resistance mechanisms and regulation is an important basis to ensure appropriate antimicrobial therapy and infection control measures in patients with pseudomonas infections.

Igor V. Chebotar

National Medical Research Center of Children’s Health, Moscow, Russia

Bocharova Yu.A.

National Medical Research Center of Children’s Health, Moscow, Russia

Nikolay A. Mayansky

National Medical Research Center of Children’s Health, Moscow, Russia

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