Clinical Microbiology and Antimicrobial Chemotherapy. 2010; 12(4):284-294
Collateral damage concept describes an adverse ecological effect associated with the use of antimicrobial agents. The main point is a selection of multidrug-resistant strains and subsequent colonization and infections caused by those microorganisms. An increased attention to this problem is explained by tremendous social and economic losses from the infections caused by pathogens which exhibit resistance to the majority of the currently available antibiotics. It is of particular significance in hospital settings and given the lack of advances in antimicrobial drug development. The key risk factors for selection of antimicrobial resistance are considered in this article. The effectiveness of measures and strategies to minimize collateral damage is also discussed.