Селекция резистентных микроорганизмов при использовании антимикробных препаратов: концепция «параллельного ущерба»

Клиническая Микробиология и Антимикробная Химиотерапия. 2010; 12(4):284-294

​ Козлов Р.С.
параллельный ущерб collateral damage антимикробные препараты резистентность
Раздел
Антимикробные препараты
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2010; 12(4):284-294

Аннотация

Концепция «параллельного ущерба» (англ. collateral damage) подразумевает побочный экологический эффект использования антимикробных препаратов (АМП), сутью которого являются селекция полирезистентных штаммов микроорганизмов и вызванные ими колонизация или инфекционный процесс. Повышенное внимание к данной проблеме медицинской общественности обусловлено колоссальными социальными и экономическими потерями от инфекционных заболеваний, вызванных устойчивыми к большинству доступных антибиотиков возбудителями, особенно в условиях стационара и на фоне недостаточного прогресса в области разработки и внедрения новых АМП. В статье рассмотрены ключевые факторы риска селекции резистентности, а также обсуждается эффективность мер, направленных на минимизацию параллельного ущерба.

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