antimicrobials

Breast surgery is a broad field that includes both surgical treatment of breast diseases and various variants of reconstructive and plastic surgeries for breast correction. Despite the fact that according to the accepted classification breast …

Piperacillin/tazobactam is a well-known β-lactam antibiotic that has been used in clinical practice since 1993. The review presents the clinical and pharmacological characteristics of piperacillin-tazobactam, the results of clinical studies and …

Objective. To assess the dynamics of antimicrobial drug consumption in the Russian Federation. Materials and Methods. Data on antimicrobials for systemic use (ATC class J01) sales for the period 2008–2022 in the hospital and outpatient segment were downloaded from the IQVIA database. The absolute quantities of purchased antimicrobials were transferred to the defined daily doses (DDD) separately for the outpatient and hospital segments for each year of observation. Results. Over the period 2008-2022 there was an increase in antimicrobials consumption from 9.

Objective. To evaluate the results of the implementation of antimicrobial stewardship (AMS) program in a multidisciplinary hospital. Materials and Methods. A retrospective intervention study was performed in the 600-bed multidisciplinary hospital of the Pirogov National Medical and Surgical Center (Moscow, Russia). The study included a number of sequential interventions, aimed at improving the prevention, diagnosis and treatment of infections, with an assessment of the following indicators dynamics: the structure of microorganisms isolated in the hospital, the level of resistance to antimicrobial drugs (AMD) among the pathogens of the ESKAPE group, the structure of prescribed AMD, as well as an assessment of clinical and economic consequences of antimicrobial resistance changes.

Objective. To evaluate prescribing patterns of antimicrobials and quantify them in relation to quality indicators in Russian multi-field hospitals. Materials and Methods. Point Prevalence Survey of Antimicrobial Consumption as a part of an international Global-PPS project was conducted in 8 multi-field hospitals in different Russian cities (Krasnoyarsk, Moscow, Omsk, Saratov, Smolensk, Ulan-Ude, Yakutsk) during the period from May till December 2021. Case records of patients who received therapeutic or prophylactic systemic antimicrobial agents were analyzed.

Prescribing safe and effective drug therapy is becoming increasingly challenging. Recently, there has been an upward trend in the number of patients experiencing polypragmasy. Thus, according to epidemiological analysis of 180,815 outpatient records …

Objective. To determine the level of basic knowledge of senior students of medical universities in the rational use of AMP. Materials and Methods. Analysis of an anonymous multicenter survey in the framework of the “KANT” project (the full name of the project is “Physicians’ (Students ’) knowledge in antimicrobials usage”), conducted in 2018–2019 in 6 cities of Russia and Kyrgyzstan. Results. The study revealed a low level of knowledge of senior students in the field of antibiotic therapy and the empirical use of AMP.

Antimicrobial resistance is a global challenge for human society. Scientists around the world are trying not to return to the time when antimicrobials were not yet discovered, and millions of people were dying from infections. This article describes …

Objective. To estimate composite indicators of systemic antibiotic consumption in the hospital segment of Saint-Petersburg in 2014–2018. Materials and Methods. Information on the volume and structure of AMP consumption in the hospital segment of St. Petersburg in 2014–2018 was obtained from AlfaRm Databases. The amount of purchased AMP was recalculated in the number of average daily maintenance doses (Defined Daily Dose, DDDs), as well as DDDs per 100 bed-days (DDDh) for each international nonproprietary name of AMP.

Adverse drug reactions affecting gastrointestinal tract, quite often with the development of antibioticassociated diarrhea, are the most common undesirable effects of antibiotic therapy in outpatient practice. This review provides modern approaches …