antimicrobials

Objective. Development and validation of a suite of mathematical models to predict national-level antimicrobial resistance (AMR) trends by integrating antimicrobial consumption (AMC) and current AMR data. Materials and Methods. Data on systemic antimicrobial consumption across 82 regions of the Russian Federation (2008–2022; source: IQVIA) and AMR levels (2013–2022; source: AMRmap.ru) were analyzed. The workflow included regional name normalization, exclusion of antimicrobials with low clinical relevance, calculation of moving averages (3–10 years) for AMR parameters, and AMC quantification in Defined Daily Doses (DDD).

Objective. To analyze physicians’ preferences regarding the pharmacotherapy of bacterial genitourinary infections (UTI) in pregnant women and assess their compliance with current clinical guidelines. Materials and Methods. The study was conducted over 2018–2022 using an anonymous questionnaire method among physicians in seven regions of Russia. A total of 227 healthcare providers participated, of whom 66.8% were general practitioners and 33.2% were obstetricians/gynecologists. Results. According to the analysis, there is an insufficient level of knowledge in the field of pharmacotherapy of UTIs in pregnant women.

Objective. To assess prevalence, etiology, antimicrobial prescribing practices and treatment outcomes of infections in intensive care units in Russia. Materials and Methods. A two-stage (the first stage – October 18, 2022, the second stage – November 18, 2022) multicenter prospective one-day observational study involved 111 intensive care units (ICUs) of 67 centers from 25 cities of the Russian Federation. Each patient was included in the study only once. Data from the medical records of all patients in the ICU on the day of the study were entered by the attending physician into a single electronic individual case report form.

This literature review summarizes actual data on the use of anti-infective drugs in the treatment of brain abscesses, in particular, otorinosnusogenic ones. Mainly the largest publications over the last decade concerning this issue were analyzed. The …

Antimicrobial therapy is an essential part of treatment of urinary tract infections, often being the only etiological and pathogenetic component of it. At the same time, the rationality of choosing an antimicrobial depends both on the sensitivity of …

Objective. Conduct a comparative assessment of the frequency and spectrum of antimicrobial resistance of Mycobacterium avium isolated from patients of a phthisiopulmonology clinic in the pre-Covid period (2018–2019) and during the COVID-19 pandemic (2020–2023). Materials and Methods. The antimicrobial sensitivity of M. avium isolates was determined to 8 antimicrobial drugs: amikacin, clarithromycin, linezolid, moxifloxacin, ciprofloxacin, doxycycline, rifabutin, rifampicin. Drug susceptibility testing was performed using serial broth microdilution method according to published CLSI guidelines, M24S, 2023.

Objective. To perform phylogenetic analysis to assess ongoing changes in population structure of Russian clinical isolates of N. gonorrhoeae. Materials and Methods. The object of the study was 34 clinical isolates of N. gonorrhoeae obtained from dermatovenerological medical institutions of the Russian Federation in the period 2022–2023. The cultures were spread on chocolate agar with 1% ISOVitalex growth additive and 1% VCAT selective additive (Becton Dickinson, USA). Mass spectrometric studies were performed using MALDI-TOF mass spectrometer (Bruker Daltonics, Germany).

Breast surgery is a broad field that includes both surgical treatment of breast diseases and various variants of reconstructive and plastic surgeries for breast correction. Despite the fact that according to the accepted classification breast …

Piperacillin/tazobactam is a well-known β-lactam antibiotic that has been used in clinical practice since 1993. The review presents the clinical and pharmacological characteristics of piperacillin-tazobactam, the results of clinical studies and …

Objective. To assess the dynamics of antimicrobial drug consumption in the Russian Federation. Materials and Methods. Data on antimicrobials for systemic use (ATC class J01) sales for the period 2008–2022 in the hospital and outpatient segment were downloaded from the IQVIA database. The absolute quantities of purchased antimicrobials were transferred to the defined daily doses (DDD) separately for the outpatient and hospital segments for each year of observation. Results. Over the period 2008-2022 there was an increase in antimicrobials consumption from 9.