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20-Year History of Carbapenems: Current Microbiological and Clinical Aspects

Clinical Microbiology and Antimicrobial Chemotherapy. 2007; 9(2):133-152
The carbapenems are one of the most important classes of antimicrobial agents with an exceptionally broad spectrum of in vitro activity in association with low toxicity and beneficial pharmacokinetic parameters. Spectrum of activity of imipenem, …

Prevention of the Selection of Resistant Staphylococci in an in vitro Dynamic Model that Simulates Fluoroquinolone Pharmacokinetics

Clinical Microbiology and Antimicrobial Chemotherapy.2004; 6(3):252-259
To study the hypothesis of the mutant selection window (MSW) in a pharmacodynamic context, the susceptibility of a clinical isolate of methicillin-resistant Stap. hylococcus aureus exposed to moxifloxacin (MOX), levofloxacin (LEV) and ciprofloxacin …