Clinical Microbiology and Antimicrobial Chemotherapy. 2009; 11(1):40-55
The carbapenems are class of beta-lactam antibiotics with exceptionally wide spectrum of activity, beneficial pharmacokinetic parameters and low toxicity as well. Such agents as imipenem and meropenem have already been succesfully used for a long time in clinical practice for treatment of severe nosocomial infections. The ertapenem appeared in 2002 represent a new class of carbapenems. It has differences from precursors in antimicrobial spectrum, including activity against ESBL and AmpC-producing microorganisms, and improved pharmacokinetics with once daily dosing. This paper provides an overview of pharmacological, microbiological and clinical data on ertapenem.