Clinical Microbiology and Antimicrobial Chemotherapy. 2009; 11(1):22-30
Invasive candidiasis is a common nosocomial infection with high attributable mortality among ICU patients. This study was performed to determine isolation rate of Candida spp. in cardiac surgical ICUs during the period of 2001–2007 and to assess changes in prevalence of different Candida species and their susceptibilities to modern antifungal agents. A total of 16352 different clinical specimens were tested. Candida species were isolated in 547 patients; there was a trend toward increase of their prevalence (from 9% to 15%) among pathogens isolated, particularly from blood and respiratory secretions. Proportion of non-albicans strains has been increased more than 2 times during the study period (form 25% in 2002 to 55% in 2007). The predominant species isolated from sputum was C. albicans (77%), followed by C. tropicalis and C. krusei. Incidence of candidemia in ICU patients has been increased 3 times during the 2005–2007. The most common Candida species isolated from blood (both in children and adults) were C. parapsilosis and C. albicans. A total of 144 Candida spp. strains were tested for susceptibility to antifungals. All strains (100%) were susceptible to amphotericin B. Susceptibilities to fluconasole and itraconasole among Candida spp. were 51% and 50%, respectively. The most active antifungal against Candida spp. was voriconasole (81%).