community-acquired pneumonia

Objective. Due to high activity against Streptococcus pneumoniae ceftaroline fosamil (CF) presents a good option for the treatment of adults with pneumococcal communityacquired pneumonia (PCAP) requiring parenteral antibacterial therapy. We aimed to assess cost-effectiveness of CF for the treatment of PCAP in a multi-field hospital in Russia from a societal perspective. Materials and Methods. Decision tree model based on the results of two 3rd phase clinical trials (FOCUS 1, FOCUS 2) was created to represent a standard approach to the management of hospitalised patients with PCAP and estimated outcomes including possible recurrence of infection, direct and delayed attributive mortality in case of initial therapy with CF 600 mg BID vs.

Objective. To estimate the incidence of communityacquired pneumonias and acute otitis media and the role of S. pneumoniae and H. influenzae in these infections in children under 5 years. Materials and Methods. Investigational program PAPIRUS (Prospective Assessment of Pneumococcal Infection in RUSsia), which included multi-center prospective epidemiological study estimating the incidence of community-acquired pneumonia (CAP) and the role of S. pneumoniae and H. influenzae in CAP and acute otitis media (AOM) in children 0-5 years of age in 3 Russian cities (Barnaul, Yekaterinburg and Murmansk) and the prospective multi-center observational cohort study evaluating the incidence of AOM in children under 5 years in the same cities had been performed during 12 months.

Over the last years, short treatment courses for different infections, including respiratory tract infections, are increasingly more discussed. This therapeutic approach has some clear benefits: improved compliance, less frequent adverse drug …

According to international post-marketing trials, levofloxacin now belongs to the antimicrobial agents being in a great demand in clinical practice. One of the main indications for its use is community-acquired pneumonia (CAP). This review article is …

The article contains modern notions of epidemiology, course, clinical and diagnostic aspects of communityacquired pneumonia caused by Mycoplasma pneumoniae, standards of its treatment and antibiotic resistance of this pathogen in the world …

Objective. To conduct a cost-effectiveness analysis of combination of azithromycin with b-lactams (cefotaxime, ceftriaxone or amoxicillin/clavulanic acid) vs levofloxacin in hospitalized adults with community-acquired pneumonia (CAP). Materials and Methods. We performed standard search and meta-analysis of prospective clinical trials (CT) to compare clinical success rate and tolerability of regimens of antibacterial therapy (ABT) under the investigation. Direct medical costs (DC) including cost of ABT and hospital stay were calculated from the perspective of Smolensk Regional Clinical Hospital and Central Clinical Hospital of Russian Academy of Sciences.

The retrospective analysis of treatment of patients with severe community-acquired pneumonia has been performed. It has demonstrated that the results of therapy with generic preparations of ceftriaxone and levofloxacin were inferior to original drug …

Severe pneumonia is associated with high mortality rates, and appropriate severity assessment plays a main role in timely admission to the hospital, including intensive care unit. There are several scores for risk (poor outcome) assessment in …

Beta-lactams remain one of the most commonly used antimicrobial classes in the treatment of community-acquired respiratory tract infections worldwide. Among them, cephalosporins take one of the main places because of their broad spectrum of activity …

Choice of empiric therapy should be based on complex of data on etiology and local antimicrobial resistance trends as well as on clinical-economic analysis. According to our results, from the pharmacoeconomic point of view the most optimal agents for …