Clinical Microbiology and Antimicrobial Chemotherapy. 2010; 12(2):146-153
Beta-lactams remain one of the most commonly used antimicrobial classes in the treatment of community-acquired respiratory tract infections worldwide. Among them, cephalosporins take one of the main places because of their broad spectrum of activity against many important pathogens and favorable safety profiles. This review considers possibilities of the use of different cephalosporins based on their pharmacokinetic and pharmacodynamic properties as well as Russian data on antimicrobial resistance, in the treatment of patients with the most significant community-acquired upper and lower respiratory tract infections.