community-acquired pneumonia | CMAC

community-acquired pneumonia

Incidence of Community-Acquired Pneumonia and Acute Otitis Media in Children 0–5 Years in Russia and Role of S. pneumoniae or H. influenzae in the Etiology of the Diseases

Objective. To estimate the incidence of communityacquired pneumonias and acute otitis media and the role of S. pneumoniae and H. influenzae in these infections in children under 5 years. Materials and Methods. Investigational program PAPIRUS (Prospective Assessment of Pneumococcal Infection in RUSsia), which included multi-center prospective epidemiological study estimating the incidence of community-acquired pneumonia (CAP) and the role of S. pneumoniae and H. influenzae in CAP and acute otitis media (AOM) in children 0-5 years of age in 3 Russian cities (Barnaul, Yekaterinburg and Murmansk) and the prospective multi-center observational cohort study evaluating the incidence of AOM in children under 5 years in the same cities had been performed during 12 months.

Short Courses of Antimicrobial Therapy: a New Treatment Paradigm for Community-Acquired Pneumonia?

Over the last years, short treatment courses for different infections, including respiratory tract infections, are increasingly more discussed. This therapeutic approach has some clear benefits: improved compliance, less frequent adverse drug …

Levofloxacin in the Treatment of Community-Acquired Pneumonia: 20-Year Successful Clinical Experience

According to international post-marketing trials, levofloxacin now belongs to the antimicrobial agents being in a great demand in clinical practice. One of the main indications for its use is community-acquired pneumonia (CAP). This review article is …

Community-Acquired Pneumonia Caused by Mycoplasma pneumoniae: Literature Review and Results of the Regional Study

The article contains modern notions of epidemiology, course, clinical and diagnostic aspects of communityacquired pneumonia caused by Mycoplasma pneumoniae, standards of its treatment and antibiotic resistance of this pathogen in the world …

Comparative Clinical and Pharmacoeconomic Analysis of Different Antimicrobial Treatment Regimens in Hospitalized Patients with Community-Acquired Pneumonia

Objective. To conduct a cost-effectiveness analysis of combination of azithromycin with b-lactams (cefotaxime, ceftriaxone or amoxicillin/clavulanic acid) vs levofloxacin in hospitalized adults with community-acquired pneumonia (CAP). Materials and Methods. We performed standard search and meta-analysis of prospective clinical trials (CT) to compare clinical success rate and tolerability of regimens of antibacterial therapy (ABT) under the investigation. Direct medical costs (DC) including cost of ABT and hospital stay were calculated from the perspective of Smolensk Regional Clinical Hospital and Central Clinical Hospital of Russian Academy of Sciences.

Questionable Efficacy of Generics in the Treatment of Severe Community-Acquired Pneumonia

The retrospective analysis of treatment of patients with severe community-acquired pneumonia has been performed. It has demonstrated that the results of therapy with generic preparations of ceftriaxone and levofloxacin were inferior to original drug …

Modern Assessment Scores for Severe Community-Acquired Pneumonia: Perspectives and Limitations

Severe pneumonia is associated with high mortality rates, and appropriate severity assessment plays a main role in timely admission to the hospital, including intensive care unit. There are several scores for risk (poor outcome) assessment in …

Cephalosporins in the Treatment of Community-Acquired Upper and Lower Respiratory Tract Infections Based on Antimicrobial Resistance Data from Russia

Beta-lactams remain one of the most commonly used antimicrobial classes in the treatment of community-acquired respiratory tract infections worldwide. Among them, cephalosporins take one of the main places because of their broad spectrum of activity …

Optimizing the Management of Community-Acquired Pneumonia in Hospitalized Patients on the Basis of Modifiable Factors

Choice of empiric therapy should be based on complex of data on etiology and local antimicrobial resistance trends as well as on clinical-economic analysis. According to our results, from the pharmacoeconomic point of view the most optimal agents for …

Laboratory Diagnosis of Community-Acquired Pneumonia

Community-acquired pneumonia (CAP) remains one of the most common and life-threatening infections. This paper represents a review of laboratory diagnosis of community-acquired pneumonia during the period of 2002– 2006. Local serological and …