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Antimicrobial susceptibility and association with serotypes of Streptococcus pneumoniae isolates in children with acute otitis media and acute sinusitis in Belarus

Objective. To study antibiotic resistance and its association with serotypes of Streptococcus pneumoniae isolated from hospitalized children with community-acquired ENT infections in Belarus during 2013-2016 and to analyze a potential for the use of different antibiotic classes in the treatment of those infections. Materials and Methods. A total of 115 strains isolated from children with acute otitis media and 18 strains isolated from children with acute rhinosinusitis were tested. Antimicrobial susceptibility testing was performed by a broth microdilution method.

Changes in antimicrobial resistance in clinical pediatric isolates of Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis in Middle Ural area

Objective. To reveal the prevalence of antimicrobial resistance of H. influenzae, S. pneumoniae, and M. catarrhalis clinical pediatric isolates in Yekaterinburg and Sverdlovsk region during 2013-2015. Materials and Methods. In total 231 H. influenzae, 289 S. pneumoniae, and 266 M. catarrhalis isolates were included in the study. Antimicrobial susceptibility testing was performed partially by disc-diffusion method and partially by automated method, depending on the local practice; β-lacamase production was detected by the nitrocefin disc test.

Clinical case of acute epididymitis in an infant with cytomegalovirus infection

A clinical case of acute epididymitis in a 5-month male infant is presented. Taking into account the occurrence of epididymitis in infancy, an intra-operative biopsy sample was tested for multiple viral pathogens by real-time polymerase chain …

Penicillin/Beta-lactamase Inhibitor Combinations in the Treatment of Bacterial Respiratory Tract Infections in Children

Over the several decades, medical and pharmaceutical science has been trying to solve the problem of antimicrobial therapy inefficiency due to rapidly increasing antimicrobial resistance. One of the antimicrobial agents being capable to overcome the …

Antimicorbial Susceptibility, Clonal and Serotype Diversity of Streptococcus pneumoniae Isolated from Children with Acute Otitis Media in Moscow

Objective. Streptococcus pneumoniae (pneumococcus) is the leading cause of acute otitis media (AOM) in children. Hereby, we describe antibiotic susceptibility, clonality, and serotype distribution of pneumococci isolated from the middle ear fluid (MEF) in children with AOM. Materials and Methods. MEF specimens from children ≤5 years of age with AOM were collected in 4 pediatric hospitals in Moscow in 2011–2013. Isolation and identification of pneumococcus was performed using standard microbiological procedures.

Paediatricians Approach to Prescribing of Systemic Antimicrobials in Outpatient Children with Upper Respiratory Tract and ENT Infections: Data from Multicenter Survey

Objective. Objectives. The study aimed to assess paediatricians knowledge of etiology and approach to systemic antimicrobials (АМ) use in outpatient children with acute respiratory tract infections. Materials and Methods. A questionnaire survey of primary care paediatricians from 17 cities of Russian Federation was performed in 2011–2013 in compliance with the unified methodology. Results. A total of 701 paediatricians (mean age 46,3±10,7, 61,5% with work experience >15 years) took part in the survey.

Comparative Efficacy of Azithromycin and Cefixime in the Treatment of Acute Infectious Invasive Diarrhea in Children

This paper describes a multicenter, randomized study to compare clinical and microbiological efficacy, and safety of azithromycin (Sumamed®, Teva) and cefixime (Suprax®, Gedeon-Richter) in the treatment of acute infectious invasive diarrhea in …

Analysis of Antibiotic Usage in Children Living in Orphanages During the 2003–2004 and 2009–2010

Analysis of antibiotic usage in children living in orphanages was performed during two time-periods: 2003–2004 and 2009–2010 with the aim to reveal key problems of antibiotic usage in this population, and to develop measures for improvement. It was …

Review of Current Guidelines on the Management of Pediatric Patients with Acute Bacterial Rhinosinusitis

Acute bacterial rhinosinusitis (ABRS) is a common disease in pediatric practice, which takes a fifth place among the causes of antimicrobials administration to children. This paper presents a review of current clinical guidelines on the management of …

Laboratory Diagnosis of Community-Acquired Pneumonia

Community-acquired pneumonia (CAP) remains one of the most common and life-threatening infections. This paper represents a review of laboratory diagnosis of community-acquired pneumonia during the period of 2002– 2006. Local serological and …