Clinical Microbiology and Antimicrobial Chemotherapy. 2016; 18(3):191-195
Over the several decades, medical and pharmaceutical science has been trying to solve the problem of antimicrobial therapy inefficiency due to rapidly increasing antimicrobial resistance. One of the antimicrobial agents being capable to overcome the most common resistance mechanisms is a fixed-dose combination of amoxicillin (penicillin) and clavulanic acid (beta-lactamase inhibitor). This article reviews the indications for use of amoxicilin/clavulanate in children with the most common upper and lower respiratory tract infections. Administration of the novel antimicrobial drug formulations considered to be more convenient and safe for pediatric patient is also considered.