children

The article describes a clinical observation of a 3 months old patient with ALK-positive histiocytosis complicated by sepsis caused by Lactobacillus paracasei. A pure culture of the microorganism was obtained by seeding on blood agar, and its …

Objective. To develop and perform pilot prospective validation of a locally adapted pediatric version of the SCAT scale for risk stratification of resistant pathogens and justification of initial empirical antimicrobial therapy in hospitalized children in a multispecialty children’s hospital. Materials and Methods. Over the period from 15 December 2025 to 15 February 2026, a single-center prospective observational study was conducted at the Morozovskaya Children’s City Clinical Hospital. The study included two sequential phases: local adaptation of the SCAT scale for risk stratification of resistant pathogens to pediatric practice and pilot clinical validation of the adapted version.

Objective. To study prevalence of macrolide resistance mutations in Mycoplasma pneumoniae isolated from children with community-acquired pneumonia in Smolensk region. Materials and Methods. The study included 774 M. pneumoniae-positive samples isolated by realtime polymerase chain reaction (real-time PCR) from pharyngeal swab in children with communityacquired pneumonia over the period 2009–2024, including 3 epidemiological rises in the incidence of M. pneumoniae (2013–2014, 2018–2019, 2023–2024). Samples of isolated DNA were examined for nucleotide substitutions in the 23S rRNA gene at positions 2058, 2059, 2611 (E.

Biapenem, in combination with polymyxin and/or tigecycline, has promising potential in the treatment of severe infections in children, including infections caused by some difficult to treat resistant pathogens. However, biapenem is currently approved …

Objective. To study structure of pathogens of community-acquired urinary tract infections (UTI) in children and adolescents under 18 years of age subpopulation of the Krasnoyarsk region as well as the activity of antimicrobials against the leading pathogen in order to optimize local empirical therapy of UTI. Materials and Methods. A total of 298 urine cultures were analyzed (164 in 2023 and 134 – in 2024). The urinalyses were obtained from children and adolescents with community-acquired UTI who hospitalized to the Krasnoyarsk Regional Clinical Center for Maternal and Child Health in 2023–2024.

Ralstonia insidiosa is not usually considered an etiologically significant microorganism capable of causing infections. This article presents a retrospective analysis of a series of hospital-acquired infections caused by R. insidiosa in 8 comorbid …

Objective. To identify specific features of the clinical course of Congo-Crimean hemorrhagic fever (CCHF) in children in order to optimize early and differential diagnosis, management tactics and treatment of pediatric patients Materials and Methods. A retrospective analysis of 159 probable and confirmed cases of Congo-Crimean hemorrhagic fever was carried out in patients admitted to the infectious diseases departments of Shymkent, district hospitals of Turkestan region for the period 2013–2022, of which 39 (24.

Сeftaroline fosamil is a fifth-generation cephalosporin and a unique β-lactam and the only currently registered in the Russian Federation cephalosporin with activity against MRSA. Сeftaroline is approved for use in pediatric practice for the …

This paper presents the first clinical case of combined pulmonary and abdominal M. genavense infection in an otherwise healthy, immunocompetent child with an early treatment response and full recovery. The favorable outcome was determined by rapid …

Objective. To study risk factors, etiology, clinical signs and treatment outcomes of invasive aspergillosis (IA) and mucormycosis combination (IAM) in children. Materials and Methods. A retrospective review of Saint-Petersburg register (1998–2021) of patients with IA was done and children with IAM were included. EORTC/MSGERG 2019 criteria were used for diagnosing and treatment results evaluation of invasive mycosis. We presented a clinical case of IAM in a child with acute lymphoblastic leukemia relapse.