Changes in antimicrobial resistance in clinical pediatric isolates of Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis in Middle Ural area

Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(2):168-175

Journal article


To reveal the prevalence of antimicrobial resistance of H. influenzae, S. pneumoniae, and M. catarrhalis clinical pediatric isolates in Yekaterinburg and Sverdlovsk region during 2013-2015.

Materials and Methods.

In total 231 H. influenzae, 289 S. pneumoniae, and 266 M. catarrhalis isolates were included in the study. Antimicrobial susceptibility testing was performed partially by disc-diffusion method and partially by automated method, depending on the local practice; β-lacamase production was detected by the nitrocefin disc test.


Among H. influenzae isolates 211 (91.4%) were β-lactamase-negative and susceptible to ampicillin, 13 (5.6%) β-lactamase-positive and resistant to ampicillin; 7 (3%) – β-lactamase-negative and resistant to ampicillin. Among S. pneumoniae strains 33.2% were non-susceptible to penicillin; susceptibility to cefotaxime and ceftriaxone was 89.2% and 93.5% respectively; 27.3% of strains were resistant to erythromycin, 20.8% – to clindamycin. β-Lactamase production was detected in 91.7% of M. catarrhalis isolates.


H. influenzae remain very high susceptibility level to β-lactams. Increase of the prevalence of S. pneumoniae non-susceptibility to penicillin and other β-lactams require further monitoring. High rate of β-lactamase production by M. catarrhalis isolates was noted.

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