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Personal Experience

Pharmacoepidemiologic, Clinical, and Microbiological Study on Antimicrobial Therapy of Inflammatory Diseases of Maxillofacial Area

This paper presents the results of a study to evaluate pharmacological therapy in inflammatory diseases of maxillofacial area in outpatient and hospital settings. The study included a review of medical records for outpatients (n = 600) and …

Knowledge Level on Etiology and Therapy of Keratitis among Ophthalmologists in Smolensk, Kaluga and Orel Regions

This paper presents the results of the study to evaluate knowledge level of ophthalmologists on risk factors, etiology, diagnosis, and treatment of keratitis. A total of 65 ophthalmologists in 3 regions (Smolensk, Kaluga, and Orel) completed …

Detection of Hungarian Pandemic MRSA Clone in Russia

Since 1961, pandemic methicillin-resistant S. aureus (MRSA) clones causing severe nosocomial infections have been distributed worldwide. The Hungarian clone having ST239 genotype and Staphylococcal cassette chromosome mec (SCCmec) type III is one of …

Clinical Significance of Bacteremia in Patients with Sepsis

An analysis of all bacteremia cases associated with systemic inflammatory response syndrome among patients hospitalized to City Clinical Hospital named after S.P. Botkin (Moscow) over the 2000–2007 was performed. A total of 303 positive blood culture …

Detection of Atopobium vaginae in Women of Childbearing Age with Bacterial Vaginosis

Bacterial vaginosis (BV) is a syndrome characterized by replacement of a normal (resident) vaginal flora with an association of anaerobic microorganisms. The most recently described novel microorganism, Atopobium vaginae, may be involved in …

Antagonistic Activity of Probiotic Bacteria

Objective. Objective: To investigate antagonistic activity of multicomponent probiotic products resulting from interactions of microorganisms; to develop bacterial selection criteria for multi-component biological products. Materials and Methods. Culture fluid of the paired probiotic strain associations: Bifidobacterium longum with Enterococcus faecium («Bifiform» product), Escherichia coli M-17 («Colibacterin» product) and Lactobacillus plantarum 8РА-3 («Lactobacterin» product) were tested for bactericidal activity against Staphylococcus aureus. Also, culture fluid of the each strain was treated with metabolites and peptidoglycan of the associative species and then tested for bactericidal activity against Staphylococcus aureus.

A New Natural Antiseptic «Galenophyllipt» for the Treatment of Staphylococcal Skin-Muscle Wound Infection in White Mice

Galenophyllipt is a new natural antiseptic for oral administration and topical use that is similar to commercially available medicinal product Chlorophyllipt. The both products are promising agents for clinical use because of their low toxicity and …

Antimicrobial Resistance of Nosocomial Staphylococci Isolated from Burn Center Patients in 2002–2008

A total of 1375 clinical strains of staphylococci isolated from patients in burn units during the 2002–2008 were tested to detect antimicrobial resistance changes during this period. Antimicrobial susceptibility testing was performed by …

Antimicrobial Resistance of S. aureus Isolated from Infants with Skin and Soft Tissue Infections

The most common pathogens of skin and soft tissue infections (SSTI) as well as pharmacodynamics parameters of different antimicrobials against S. aureus are considered in this paper. A total of 80 clinical S. aureus isolates obtained from children (0 …

Etiology and Antimicrobial Resistance of Hospital-acquired and Community-acquired Intra-Abdominal Infections in ICUs of Two Teaching Hospitals

Objective. To investigate the etiology and antimicrobial resistance patterns of aerobic bacterial pathogens in community- and hospital-acquired intra-abdominal infections (IAI) in the ICUs of two teaching hospitals in one particular city. Materials and Methods. A total of 168 patients with peritonitis (122 community-acquired, 46 nosocomial) were included in the study. Susceptibility testing was performed by agar dilution method according to CLSI recommendations. Results. Clinically significant aerobic pathogens were isolated in 61.