Clinical Microbiology and Antimicrobial Chemotherapy. 2009; 11(4):356-361
The most common pathogens of skin and soft tissue infections (SSTI) as well as pharmacodynamics parameters of different antimicrobials against S. aureus are considered in this paper. A total of 80 clinical S. aureus isolates obtained from children (0 to 3 years of age) with SSTI in Smolensk outpatient clinics during 2006–2008 were tested. Susceptibility testing was performed by agar dilution method using the following antimicrobial agents: fusidic acid, gentamicin, mupirocin, ciprofloxacin, levofloxacin, erythromycin, clindamycin, lincomycin, tetracycline, chloramphenicol, co-trimoxazole, vancomycin, linezolid, rifampicin, oxacillin, netilmicin. The most in vitro active antimicrobials (susceptibility 100%) were linezolid, vancomycin, mupirocin, fusidic acid, netilmicin, and co-trimoxazole. High resistance rates among tested S. aureus isolates were observed for ciprofloxacin (32%), tetracycline (31%), chloramphenicol (26.5%), clindamycin (21%), erythromycin (26%), gentamicin (16%), and levofloxacin (16%). Incidence of methicillin-resistant S. aureus (MRSA) was 16%. Based on the susceptibility testing results, appropriate antimicrobials for empiric therapy of infants with SSTI in outpatient settings were proposed.