Diseases and Pathogens | CMAC

Diseases and Pathogens

Rhodococcus spp.: Clinical Importance, Diagnosis and Antimicrobial Therapy

The clinical significance of nocardioform bacteria isolated recently in a distinct genus Rhodococcus, as pathogens of infectious diseases in human also has not been sufficiently studied and specified. In the literature there are described a slightly …

Prevention of Hospital-Acquired Pneumonia in Patients with Acute Stroke

Hospital-acquired pneumonia (HAP) is a permanent problem of hospitals, especially intensive care units, where multiple factors such as invasive tests and treatments, aggressive medical therapy, and complex conditions of patient care contribute to …

Short Courses of Antimicrobial Therapy: a New Treatment Paradigm for Community-Acquired Pneumonia?

Over the last years, short treatment courses for different infections, including respiratory tract infections, are increasingly more discussed. This therapeutic approach has some clear benefits: improved compliance, less frequent adverse drug …

The New Approach to the Topical Therapy of Onychomycoses

Onychomycosis is a fungal infection of nails of fingers of the hands or feet, resulting in thinning, and the subsequent destruction, discoloration and desquamation of the nail plate from the nail bed. The etiology of onychomycosis in most cases are …

Review of the 2012 IDSA Guidelines on the Management of Diabetic Foot Infections

Diabetic foot infections (DFIs) are a frequent clinical problem. Properly managed, most of them can be cured, but many patients needlessly undergo amputations because of improper diagnostic and therapeutic approaches. Foot infection should be defined …

Community-Acquired Pneumonia Caused by Mycoplasma pneumoniae: Literature Review and Results of the Regional Study

The article contains modern notions of epidemiology, course, clinical and diagnostic aspects of communityacquired pneumonia caused by Mycoplasma pneumoniae, standards of its treatment and antibiotic resistance of this pathogen in the world …

Aggregatibacter actinomycetemcomitans: Clinical Significance, Diagnosis, Antimicrobial Therapy

Currently, HACEK group bacteria are a causative agent in 3% of infectious endocarditis cases; of which Aggregatibacter actinomycetemcomitans is the most frequent pathogen. However, this pathogen can be obtained from patients with meningitis, brain …

Medical Problems Associated with Bacterial Biofilms

This paper represents a review of currently available data on microbial communities and biofilms as an important clinical problem. Structure and morphology of microbial biofilm as well as stages and mechanisms of its formation, and genes and factors …

Comparative Clinical and Pharmacoeconomic Analysis of Different Antimicrobial Treatment Regimens in Hospitalized Patients with Community-Acquired Pneumonia

Objective. To conduct a cost-effectiveness analysis of combination of azithromycin with b-lactams (cefotaxime, ceftriaxone or amoxicillin/clavulanic acid) vs levofloxacin in hospitalized adults with community-acquired pneumonia (CAP). Materials and Methods. We performed standard search and meta-analysis of prospective clinical trials (CT) to compare clinical success rate and tolerability of regimens of antibacterial therapy (ABT) under the investigation. Direct medical costs (DC) including cost of ABT and hospital stay were calculated from the perspective of Smolensk Regional Clinical Hospital and Central Clinical Hospital of Russian Academy of Sciences.

Molecular Epidemiology of Staphylococcus aureus in Russian Pediatric Hospitals

Objective. To reveal molecular types of nosocomial and community-acquired strains of S. aureus in different regions of Russia. Materials and Methods. 575 (187 MRSA and 388 MSSA) strains, isolated from pediatric patients during multicenter studies (1997–2008) from 36 medical institutions in 24 Russian cities were included in the study. For molecular typing 186 strains with unique resistance profile within each ward of each medical institution were selected. The following typing methods were used: MLVA, spa, SCCmec and MLST.