Clinical Microbiology and Antimicrobial Chemotherapy. 2013; 15(4):261-269
This paper reviews a current state of the lymphogranuloma venereum in developed countries. Lymphogranuloma venereum is a sexually transmitted disease caused by Chlamydia trachomatis serovars L1, L2, and L3. Over the last years, this infection has raised its relevance because of multiple outbreaks in Europe and US. The following specific features of this infection were found: most cases were caused by serovar L2, affected mainly homosexual men, and clinically presented as a proctitis. The most recent cases were reported predominantly in HIV-infected patients. Polymerase chain reaction (PCR) is usually used to differentiate between strains causing lymphogranuloma venereum and other Chlamydia trachomatis strains. Doxycycline is a drug of choice for lymphogranuloma venereum and requires 21-day treatment course. In order to reduce incidence of lymphogranuloma venereum, epidemiological data as well as genetic and microbiologic characteristics of this pathogen should be recognized.