Rhodococcus spp.: Clinical Importance, Diagnosis and Antimicrobial Therapy

Clinical Microbiology and Antimicrobial Chemotherapy. 2013; 15(3):173-183

​ Trapeznikova B.V., Ivanova T.N., Kozhedub A.P.
Rhodococcus sinusitis orbital cellulitis diagnosis therapy
Section
Diseases and Pathogens
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2013; 15(3):173-183

Abstract

The clinical significance of nocardioform bacteria isolated recently in a distinct genus Rhodococcus, as pathogens of infectious diseases in human also has not been sufficiently studied and specified. In the literature there are described a slightly more than 100 cases of disease in humans caused by the representatives of the genus Rhodococcus (lung abscesses, endophthalmitis, bacteriemia, etc). The peculiarity of the cases had background the presence of immunodeficiency state (often HIV-infection). This article describes a clinical case of severe pansinusitis and orbital cellulitis caused by Rhodococcus equi, as well as an overview of the available data on the clinical significance, diagnosis and antimicrobial therapy of this pathogen.

  • 1. Magnusson H. Spezifische infektiose pneumonie beim fohlen: ein neuer eitererreger beim pferd [in German]. Arch Wiss Prakt Tierheilkd 1923; 50:22-38.
  • 2. Golub B., Falk G., Spink W.W. Lung abscess due to Corynebacterium equi: report of first human infection. Ann Intern Med 1967; 66:1174-7.
  • 3. Van Etta L.L, Filice G.A, Ferguson R.M., Gerding D.N. Corynebacterium equi: a review of 12 cases of human infection. Rev Infect Dis 1983; 5:1012-8.
  • 4. Prescott J.F. Rhodococcus equi: an animal and human pathogen. Clin Microbiol Rev 1991; 4:20-34.
  • 5. Cornish N., Washington J.A. Rhodococcus equi infections: clinical features and laboratory diagnosis. Curr Clin Top Infect Dis 1999; 19:198-215.
  • 6. Takai S., Ohbushi S., Koike K., Tsubaki S., Oishi H., Kamada M. Prevalence of virulent Rhodococcus equi in isolates from soil and feces of horses from horsebreeding farms with and without endemic infections. J Clin Microbiol 1991; 29:2887-9.
  • 7. Rasmussen T.T, Kirkeby L.P, Poulsen K, Reinholdt J., Kilian M. Resident aerobic microbiota of the adult human nasal cavity. APMIS 2000; 108:663-75.
  • 8. Scotton P.G, Tonon E., Giobbia M., Gallucci M., Rigoli R., Vaglia A. Rhodococcus equi nosocomial meningitis cured by levofloxacin and shunt removal. Clin Infect Dis 2000; 30:223-4.
  • 9. Ившина И.Б. Бактерии рода Rhodococcus (иммунодиагностика, детекция, биоразнообразие) Автореферат докт. дисс. Пермь; 1997 г.
  • 10. Giguere S., Hondalus M.K., Yager J.A., Darrah P., Mosser D.M., Prescott J.F. Role of the 85-kilobase plasmid and plasmid-encoded virulence-associated protein A in intracellular survival and virulence of Rhodococcus equi. Infect Immun 1999; 67:3548-57.
  • 11. Takai S., Sasaki Y., Ikeda T., Uchida Y., Tsubaki S., Sekizaki T. Virulence of Rhodococcus equi isolated from patients with and without AIDS. J Clin Microbiol 1994; 32:457-60.
  • 12. Takai S., Imai Y., Fukunaga N., et al. Identification of virulence associated antigens and plasmids in Rhodococcus equi from patients with AIDS. J Infect Dis 1995; 172:1306-11.
  • 13. Lührmann A., Mauder N., Sydor T., et al. Necrotic death of Rhodococcus equi - infected macrophages is regulated by virulence-associated plasmids. Infection and Immun 2004; 4:853-62.
  • 14. Navas J., González-Zorn B., Ladrón N., Garrido P., José A., Vázquez-Boland. Identification and mutagenesis by allelic exchange of choe, encoding a cholesterol oxidase from the intracellular pathogen Rhodococcus equi. J Bacteriol 2001; 8:4796-805.
  • 15. Бадиков В.Д., Беспалова Г.И. Аэробные (факультативно-анаэробные) грамположительные палочки. Классификация и номенклатура. Учебное пособие для врачей – СПб.: ART-Xpress, 2009: С. 50-52.
  • 16. Weinstock D.M., Brown A.E. Rhodococcus equi: An emerging pathogen. Clin Infect Dis 2002; 34:1379-85.
  • 17. Prescott J.F. Rhodococcus equi: an animal and human pathogen. Clin Microbiol Rev 1991; 4:20-34.
  • 18. Бадиков В.Д., Беспалова Г.И. Аэробные (факультативно-анаэробные) грамположительные палочки. Морфологические и культуральные свойства. Учебное пособие для врачей - СПб.: ART-Xpress. - 2009. - с. 65-70.
  • 19. Drancourt M., Bonnet E., Gallais H., et al. Rhodococcus equi infection in patients with AIDS. J Infect 1992; 24:123-31.
  • 20. Kedlaya I., Ing M.B., Wong S.S. Rhodococcus equi infections in immunocompetent hosts: case report and review. Clin Infect Dis 2001; 32:39-46.
  • 21. Egawa T., Hara H., Kawase I., et al. Human pulmonary infection with Сorynebacterium equi. Eur Respir J 1990; 3:240-2.
  • 22. Gray K.J., French N., Lugada E., Watera C., Gilks C.F. Rhodococcus equi and HIV-1 infection in Uganda. J Infect 2000; 41:227-31.
  • 23. Po-Ren Hsueh, Chien-Ching Hung, Lee-Jeng Teng, et al. Report of invasive Rhodococcus equi infection in Taiwan, with an emphasis on the emergence of multidrug-resistant strains. Clin Infect Dis 1998; 27:370-5.
  • 24. Donisi A., Suardi M.G., Casari S. et al. Rhodococcus equi infection in HIV-infected patients. AIDS 1996; 10:359-62.
  • 25. Harvey R.L., Sunstrum J.C. Rhodococcus equi infection in patients with and without human immunodeficiency virus infection. Rev Infect Dis 1991; 13:139-45.
  • 26. Munoz P., Palomo J., Guembe P., Rodriguez-Creixems M., Gijon P., Bouza E. Lung nodular lesions in heart transplant recipients. J Heart Lung Transplantation 2000; 19:660-7.
  • 27. La Rocca E., Gesu G., Caldara R., et al. Pulmonary infection caused by Rhodococcus equi in a kidney and pancreas transplant recipient: a case report. Transplantation 1998; 65:1524–5.
  • 28. Fischer L., Sterneck M., Albrecht H., et al. Vertebral osteomyelitis due to Rhodococcus equi in a liver transplant recipient. Clin Infect Dis 1998; 26(3):749-52.
  • 29. Kedlaya I., Michael B.I., Sammy S.W. Rhodococcus equi infections in immunocompetent hosts: case report and review. Clin Infect Dis 2001; 32(3):39-46.
  • 30. Kamboj M., Kalra A., Kak V. Rhodococcus equi brain abscess in a patient without HIV. J Clin Pathol 2005; 58:423-25.
  • 31. Matsushita H., Hanayama N., Hobo K., Kuba K., Takazawa A. Infectious endocarditis caused by Rhodococcus equi. Ann Thorac Surg 2010; 89:957-59.
  • 32. Stephanie N., Christopher S., Jun H., Clifford R., et al. Severe cavitary pneumonia caused by a non-equi Rhodococcus species in an immunocompetent patient. Respir Care 2013; 58(4):47-50.
  • 33. Weingarten J.S., Huang D.Y, Jackman J.D. Rhodococcus equi pneumonia: an unusual early manifestation of the acquired immunodeficiency syndrome (AIDS). Chest 1988; 94:195-6.
  • 34. Bowersock T.L., Salmon S.A., Portis E.S., et al. MICs of oxazolidinones for Rhodococcus equi strains isolated from humans and animals. Antimicrob Agents Chemother 2000; 44:1367-9.
  • 35. Lasky J.A., Pulkingham N., Powers M.A., Durack D.T. Rhodococcus equi causing human pulmonary infection: review of 29 cases. South Med J 1991; 84:1217-20.
  • 36. Verville T.D., Huycke M.M., Greenfield R.A., et al. Rhodococcus equi in humans: 12 cases and a review of the literature. Medicine (Baltimore) 1994; 73:119-32.
  • 37. Ferruzzi S., Mamprim F., Vailati F. Rhodococcus equi infection in non–HIV-infected patients: two case reports and review. Clin Microbiol Infect 1997; 3:12-8.
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