antimicrobial resistance | CMAC

antimicrobial resistance

Metallo-β-Lactamases: Importance and Detection Methods in Gram-Negative Non-Fermenting Bacteria

More frequently metallo-beta-lactamase (MβL) production becomes a reason of resistance to beta-lactam antibiotics among non-fermentative Gram-negative bacteria, foremost among Pseudomonas spp. and Acinetobacter spp. pathogens. It is evident that …

Antimicrobial Resistance of Clinical Strains of H. influenzae Isolated from Children in Yekaterinburg During 2000–2005

Susceptibility testing of 268 clinical strains of H. influenzaе isolated from children in Yekaterinburg during 2000–2005 was performed by disc diffusion method. Resistance to ampicillin was 13%, to II generation cephalosporins – 3%. There was the …

Current state of Anti-Anaerobic Therapy

Over the last years there is an increase in number of publications that address to the failure of empirical therapy of anaerobic infections which is due to the antimicrobial resistance of pathogens. Hence, it is important to have valid local data on …

Non-Fermenting GramNegative Nosocomial Pathogens in Russian ICUs: Antimicrobial Resistance Problems

In vitro susceptibility study strains of Acinetobacter baumannii and Pseudomonas aeruginosa isolated from patients with nosocomial infections in 31 Russian ICUs was performed (in the framework of «RESORT» survey). The following antibiotics were …

Antimicrobial Resistance of Streptococcus pneumoniae in Russia in 1999–2005: Results of Multicentre Prospective Studies PEHASus-I and PEHASus-II

Objective. Objective: To assess the level, structure and phenotypes of antimicrobial resistance of Streptococcus pneumoniae in different regions of Russia and to evaluate their dynamics in period from 1999 to 2005. Materials and Methods. A total of 1704 S. pneumoniae from 23 cities of Central, North-Western, Southern, Privolgsk, Ural, Siberian and Far-Eastern regions of Russia were included into the study from 1999 to 2005. Susceptibility to 17 antimicrobials was determined by microdilution in accordance with Clinical and Laboratory Standards Institute/National Committee for Clinical Laboratory Standards (CLSI/NCCLS).

Comparative Analysis of Etiology and Antimicrobial Resistance of the Main Nosocomial Pathogens Isolated from the ICUs in Ekaterinburg

Nosocomial infections are very important cause of morbidity and mortality in all developed countries. Results of antimicrobial resistance surveillance performed in the intensive care units of Ekaterinburg (Russia) are presented in the paper. The …

β-Lactam/β-Lactamase Inhibitor Combinations: Role in the Antimicrobial Therapy

At present, β-lactams are the most commonly used antimicrobials, but their clinical efficacy may be reduced because of the spread of antimicrobial resistance. The most important mechanism of resistance to β-lactams is an inhibition by the microbial …

Resistance in Shigella spp. and Modern Approaches to Antimicrobial Therapy of Shigellosis

A variety of resistance mechanisms and free transfer of resistance genes whithin a gender as well as among Enterobacteriaceae lead to a number of problems in the choice of antibacterial therapy of shigellosis. Many conventional antimicrobials used …

The Etiology of Acute Bacterial Sinusitis. Results of SSSR Multicenter Microbiological Study

Materials and Methods. The aim of the study was to determine the structure of bacterial pathogens and their antimicrobial resistance in adult patients with acute maxillary sinusitis. A total of 311 strains isolated from 442 adult patients with acute maxillary sinusitis were included in the study during 2000–2003. Results. Clinically significant bacterial pathogens were isolated in 65.4% of patients; among them single microorganism were found in 87.3% of cases, >2 – in 12.

Infections Caused by Nonfermenting Gram-negative Rods: Epidemiological, Microbiological and Clinical Features

Nonfermenting gram-negative rods (NGR) are one of the leading nosocomial pathogens. Among them Pseudomonas aeruginosa, Acinetobacter baumannii, Pseudomonas aeruginosa, Acinetobacter spp., Burkholderia spp., Stenotrophomonas spp., and Chryseobacterium …