Clinical Microbiology and Antimicrobial Chemotherapy. 2005; 7(4):350-368
A variety of resistance mechanisms and free transfer of resistance genes whithin a gender as well as among Enterobacteriaceae lead to a number of problems in the choice of antibacterial therapy of shigellosis. Many conventional antimicrobials used for treatment of shigellosis such as ampicillin, co-trimoxazole and tetracyclynes lost their activity. The role of the different classes of antimicrobials in the treatment of shigellosis is discussed in this review.