Clinical Microbiology and Antimicrobial Chemotherapy. 2006; 8(3):243-259
In vitro susceptibility study strains of Acinetobacter baumannii and Pseudomonas aeruginosa isolated from patients with nosocomial infections in 31 Russian ICUs was performed (in the framework of «RESORT» survey). The following antibiotics were tested: amikacin, cefepime, cefoperazone, cefoperazone/sulbactam, ceftazidime, ciprofloxacin, gentamicin, imipenem, levofloxacin, meropenem, piperacillin, piperacillin/tazobactam, and polymyxin B (for P. aeruginosa). The most active against tested A. baumannii isolates were cefoperazone/sulbactam, imipenem and meropenem. Rates of nonsusceptibility to these antimicrobial agents were 2.2%, 2.2% and 3.5%, respectively. The following antibiotics were the least active: cefoperazone, gentamicin and piperacillin; 97.8%, 89.1% and 91.7% of tested A. baumannii isolates were nonsusceptible, respectively. In this study 74.7%, A.baumannii were nonsusceptible to piperacillin/tazobactam. P. aeruginosa were highly resistant to all antibiotics tested, except polymyxin B (5.8% nonsusceptible isolates). Among the other antibiotics imipenem, meropenem, piperacillin/tazobactam and amikacin were the most active. There were 39.0% and 41.4% nonsusceptible isolates to imipenem and meropenem, respectively. Resistance rates to amikacin and piperacillin/tazobactam were 41.6% and 42.4%, respectively. Resistance rate to ceftazidime was 47.9%. Resistance to the other cephalosporins varied from 58.6% to 72.6%. Fluoroquinolones exhibited low in vitro activity against P. aeruginosa with more than 65% of nonsusceptible isolates.