Molecular epidemiology of mcr gene group | CMAC

Molecular epidemiology of mcr gene group

Clinical Microbiology and Antimicrobial Chemotherapy. 2020; 22(4):287-300

​ Shedko E.D., Timoshina O.Yu., Azyzov I.S.
10.36488/cmac.2020.4.287-300
antimicrobial resistance genetic determinants resistance genes polymyxins mcr molecular diagnosis
Section
Antimicrobial Resistance
Type
Review
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2020; 22(4):287-300

Abstract

Colistin and polymyxin B are the “last reserve” antimicrobials for the treatment of extensively drug-resistant Gram-negative bacterial infections. The rapidly increasing prevalence of polymyxin resistance mediated by the mcr gene localized on plasmid DNA currently poses a high epidemiological threat. In order to control a distribution of mcr genes, it is necessary to develop highly accurate, highly sensitive and easy-to-use diagnostic tools. This paper provides a review of the most relevant studies on the molecular epidemiology as well as current approaches to microbiological and molecular detection of mcr group genes.

Elizaveta D. Shedko

Central Research Institute of Epidemiology, Moscow, Russia

Timoshina O.Yu.

Central Research Institute of Epidemiology, Moscow, Russia

Azyzov Ilya Sulejmanovich

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

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