Молекулярная эпидемиология генов группы mcr

Елизавета Дмитриевна Шедько; О.Ю.  Тимошина; Илья Сулейманович Азизов

doi:10.36488/cmac.2020.4.287-300

Молекулярная эпидемиология генов группы mcr

Клиническая микробиология и антимикробная химиотерапия. 2020; 22(4):287-300

Шедько Е.Д., Тимошина О.Ю., Азизов И.С.

10.36488/cmac.2020.4.287-300

антибиотикорезистентность генетические детерминанты гены резистентности полимиксины mcr молекулярная диагностика

Раздел

Антибиотикорезистентность

Тип

Обзор

Публикация

Клиническая микробиология и антимикробная химиотерапия. 2020; 22(4):287-300

Аннотация Авторы Литература PDF Статистика Репринты

Аннотация

Колистин, относящийся к классу полимиксинов, является так называемым антибиотиком последнего резерва и используется в борьбе с заболеваниями, вызванными бактериальными патогенами с множественной лекарственной устойчивостью. Стремительное распространение резистентности к полимиксинам, опосредованной локализованным на плазмидной ДНК геном mcr, может представлять высокую эпидемиологическую опасность. Для эффективного контроля за распространением генов группы mcr необходимо создание высокоточных, высокочувствительных и простых в применении тест-систем. В данном обзоре рассматриваются наиболее актуальные исследования в области молекулярной эпидемиологии, а также описываются существующие в настоящий момент подходы к микробиологической и молекулярно-биологической диагностике генов группы mcr.

Шедько Елизавета Дмитриевна

shedko@cmd.su

ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора, Москва, Россия

Тимошина О.Ю.

ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора, Москва, Россия

Азизов Илья Сулейманович

0000-0001-5553-9829

НИИ антимикробной химиотерапии ФГБОУ ВО СГМУ Минздрава России, Смоленск, Россия

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