Bacteriological and Molecular Diagnosis of Bacteremia in HIV-positive Patients

Clinical Microbiology and Antimicrobial Chemotherapy. 2014; 16(4):248-253

Journal article


The study aimed to compare efficacy of microbiologic and molecular genetic methods in identification of an infectious agent in blood samples from HIV-positive patients with septic symptoms. 130 venous blood samples were studied using microbiological and molecular methods. Infectious agent was identified in 45.4% cases, by culture — in 37.7, by real-time PCR for mycobacterium tuberculosis complex specific DNA — in 10 additional samples (7.7%). M. tuberculosis was found in 29.2% of all verified cases, M. avium and M. intracellulare — in 9.2%. The battery of molecular and modern microbiological tests led to increased efficacy of etiological diagnosis in patients with sepsis and decreased tests’ turnaround time.

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