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sepsis

Rapid syndromic approach to diagnosis of bacteremia – results of the first experience

Objective. To describe results of the first experience of using a syndromic approach to the diagnosis of bacteremia using multiplex panels for real-time polymerase chain reaction (real-time PCR). Materials and Methods. The prospective study included 10 consecutive positive blood cultures obtained from 10 patients in the intensive care unit after cardiac surgery. Hemocultures were carried out in BacT/ ALERT FA Plus vials using a BacT/ALERT 3D 120 incubator (bioMérieux, France).

Antimicrobial therapy of sepsis caused by carbapenem-resistant Klebsiella pneumoniae in patients with hematological malignancies

Objective. To compare the efficacy of ceftazidime-avibactam and aztreonam combination therapy with “standard” therapy in patients with hematological malignancies and sepsis, caused by carbapenemresistant K. pneumoniae. Materials and Methods. In this open, single center prospective-retrospective, cohort study, during 2019–2022, we analyze medical documentation of 81 hospitalized patients with hematologic malignancies and K. pneumoniae sepsis. K. pneumoniae was identified by MALDI-TOF mass-spectrometry; antimicrobial susceptibility testing was performed in accordance with current versions of EUCAST guidelines.

Epidemiology and impact of colonization by multidrug-resistant Gram-negative bacteria on bloodstream infections in early phase of allogeneic hematopoietic stem cell transplantation

Objective. To study epidemiology and impact of colonization by multidrug-resistant Gram-negative bacteria (MDRGNB) on bloodstream infections (BSI) during allogeneic hematopoietic stem cell transplantation (allo-HSCT). Materials and Methods. The retrospective study included 288 patients received the first allo-HSCT between 2018 and 2019. The median age was 32 (18–66) years, male – 53% (n = 152). The majority of patients had acute leukemia – 62% (n = 178) and received transplant from matched unrelated – 42% (n = 120) or haploidentical donor – 26% (n = 75).

Biomarkers of infection in the optimization of antibacterial therapy: justified expectations

Despite the continuous improvement of approaches to antimicrobial therapy and the emergence of new highly effective antibiotics, severe bacterial infections being a significant cause of morbidity and mortality remain a top of mind issue for …

Bacteriological and Molecular Diagnosis of Bacteremia in HIV-positive Patients

The study aimed to compare efficacy of microbiologic and molecular genetic methods in identification of an infectious agent in blood samples from HIV-positive patients with septic symptoms. 130 venous blood samples were studied using microbiological …

Modern Methods for Laboratory Diagnosis of Sepsis

The review deals with modern methods of indication of infectious agents in the blood. From methodological point of view, they can be divided into two main groups: bacteriologic and molecular. The first group of methods used and improved almost from …

Infections in Russian ICUs: Results of the Nationwide Multicenter Study

Epidemiological data on the prevalence of infections in ICU is crucial for clinical practice. At the same time in Russia only very limited local information was available. So, the aim of the present study was to evaluate the prevalence and etiology …

Clinical Significance of Bacteremia in Patients with Sepsis

An analysis of all bacteremia cases associated with systemic inflammatory response syndrome among patients hospitalized to City Clinical Hospital named after S.P. Botkin (Moscow) over the 2000–2007 was performed. A total of 303 positive blood culture …

Surviving Sepsis Campaign 2008: Overview and Analysis

The present article represents an overview and critical analysis of new international clinical guidelines on the management of patients with severe sepsis and septic shock that were prepared with involvement of 15 medical associations, united for …

Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock

Reproduced with permission from the Society of Critical Care Medicine, the European Society of Intensive Care and Medicine and the International Sepsis Forum.