sepsis

Objective. To identify associations between functional polymorphisms in genes of the immune, endothelial, and coagulation systems and the severity and outcomes of sepsis to validate genetic risk predictors. Materials and Methods. This single-center prospective study included 124 patients aged of 1 month to 28 years with hematological malignancies, in whom 152 cases of sepsis were recorded. Genotyping of 20 polymorphic variants in 16 genes was performed using capillary Sanger sequencing.

Sepsis is a life-threatening condition resulting from a dysregulated immune response to infection and characterized by multiple organ dysfunction. Historically, the contribution of viruses to sepsis pathogenesis has been underestimated, largely due …

Objective. To evaluate level of knowledge, attitudes, and practices (KAP) concerning sepsis and antimicrobial resistance (AMR) among medical students in the Russian Federation. Materials and Methods. A multicenter, cross-sectional survey was conducted among students from six medical universities using a validated questionnaire (Cronbach’s alpha: 0.74) developed based on the Knowledge, Attitudes, and Practices (KAP) model. Results. The study included 1052 respondents, comprising 315 (29.9%) males and 737 (70.1%) females, with a median age of 22 [21; 24] years.

This review provides the characteristics of representatives of the Weissella genus, including W. confusa, W. cibaria, and W. viridescens. The morphological, cultural, biochemical serological properties of these microorganisms belonging to the genus …

Objective. To describe results of the first experience of using a syndromic approach to the diagnosis of bacteremia using multiplex panels for real-time polymerase chain reaction (real-time PCR). Materials and Methods. The prospective study included 10 consecutive positive blood cultures obtained from 10 patients in the intensive care unit after cardiac surgery. Hemocultures were carried out in BacT/ ALERT FA Plus vials using a BacT/ALERT 3D 120 incubator (bioMérieux, France).

Objective. To compare the efficacy of ceftazidime-avibactam and aztreonam combination therapy with “standard” therapy in patients with hematological malignancies and sepsis, caused by carbapenemresistant K. pneumoniae. Materials and Methods. In this open, single center prospective-retrospective, cohort study, during 2019–2022, we analyze medical documentation of 81 hospitalized patients with hematologic malignancies and K. pneumoniae sepsis. K. pneumoniae was identified by MALDI-TOF mass-spectrometry; antimicrobial susceptibility testing was performed in accordance with current versions of EUCAST guidelines.

Objective. To study epidemiology and impact of colonization by multidrug-resistant Gram-negative bacteria (MDRGNB) on bloodstream infections (BSI) during allogeneic hematopoietic stem cell transplantation (allo-HSCT). Materials and Methods. The retrospective study included 288 patients received the first allo-HSCT between 2018 and 2019. The median age was 32 (18–66) years, male – 53% (n = 152). The majority of patients had acute leukemia – 62% (n = 178) and received transplant from matched unrelated – 42% (n = 120) or haploidentical donor – 26% (n = 75).

Despite the continuous improvement of approaches to antimicrobial therapy and the emergence of new highly effective antibiotics, severe bacterial infections being a significant cause of morbidity and mortality remain a top of mind issue for …

The study aimed to compare efficacy of microbiologic and molecular genetic methods in identification of an infectious agent in blood samples from HIV-positive patients with septic symptoms. 130 venous blood samples were studied using microbiological …

The review deals with modern methods of indication of infectious agents in the blood. From methodological point of view, they can be divided into two main groups: bacteriologic and molecular. The first group of methods used and improved almost from …