Clinical Microbiology and Antimicrobial Chemotherapy. 2013; 15(1):56-65
Objective. Objectives. To study incidence and changes of fluoroquinolone resistance among Mycobacterium tuberculosis in Novosibirsk region, and to determine fluoroquinolone contribution to drug resistance selection in M. tuberculosis population.
Materials and Methods. A total of 344 clinical isolates of M. tuberculosis obtained from patients with newly diagnosed tuberculosis during the periods of 2000–2002 and 2006–2010 were tested for susceptibility to fluoroquinolones. This study included 141 isolates susceptible to first-line drugs and 83 isolates resistant to isoniazid and rifampicin (multi-drug resistance [MDR]), and 120 isolates resistant to one or more anti-TB drugs, but without MDR.