Независимое приобретение резистентности к хинолонам у клонально-родственных нозокомиальных штаммов Salmonella Typhimurium вследствие гипермутабельности | КМАХ

Независимое приобретение резистентности к хинолонам у клонально-родственных нозокомиальных штаммов Salmonella Typhimurium вследствие гипермутабельности

Клиническая Микробиология и Антимикробная Химиотерапия. 2012; 14(2):153-161

​ Козырева В.К., Эйдельштейн М.В., Тапальский Д.В., Азизов И.С., Козлов Р.С.
Salmonella Typhimurium нозокомиальные инфекции антибиотикорезистентность хинолоны гипермутабельность
Раздел
Антибиотикорезистентность
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2012; 14(2):153-161

Аннотация

У выделенных на территории России, Беларуси и Казахстана нозокомиальных штаммов Salmonella Typhimurium, продуцирующих β-лактамазу расширенного спектра CTX-M-5 и принадлежащих к одной генетической группе, выявлена высокая частота устойчивости к хинолонам (43,1%). Резистентность во всех случаях была связана с наличием единичных точечных мутаций в QRDR области субъединицы А ДНК гиразы (GyrA), однако у разных штаммов были обнаружены различные аминокислотные замены в позициях 83 или 87 GyrA, что свидетельствует об их независимом приобретении. Высокая частота резистентности к хинолонам и разнообразие замен в QRDR объясняются повышенной частотой мутирования (гипермутабельностью), которая была выявлена у всех изолятов описанной клональной группы.

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